MRI alterations in immunomodulation

Der Nervenarzt
K Guggenberger, H Urbach

Abstract

In this review article, typical imaging findings of diseases elicited by immunomodulatory drugs are presented. Progressive multifocal leucoencephalopathy (PML), a subacute infection due to reactivation of the JC virus, has a typical magnetic resonance imaging (MRI) pattern, which must be considered in the framework of immunomodulatory multiple sclerosis (MS) treatment with natalizumab, fingolimod, rituximab and fumarate and also in lymphoproliferative diseases or other forms of immunosuppression. Restoration of the immune system may result in an overlapping and overwhelming immune response in terms of an immune reconstitution inflammatory syndrome (IRIS). Further conditions with typical MRI patterns comprise methotrexate-associated leucoencephalopathy and posterior reversible encephalopathy syndrome (PRES). In immunotherapy with activation of T‑lymphocytes, attention should always be paid to the fact that the T‑lymphocytes activated by different processes not only target the diseased tissue but also normal brain tissue.

References

Dec 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R W WalkerB Caparros
Aug 2, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·W KükerU Herrlinger
Sep 1, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S BoeckV Heinemann
Oct 20, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H InabaN C Daw
May 13, 2009·The Journal of Infectious Diseases·Adrian EgliHans H Hirsch
May 29, 2009·AJNR. American Journal of Neuroradiology·K J CarpenterF R Murtagh
May 11, 2011·Archives of Neurology·David B CliffordKenneth L Tyler
May 18, 2012·The New England Journal of Medicine·Gary BloomgrenCarmen Bozic
Jun 8, 2013·The Cochrane Database of Systematic Reviews·Graziella FilippiniGeorgia Salanti
Apr 9, 2015·The New England Journal of Medicine·Thorsten RosenkranzChristoph Terborg
Oct 21, 2015·Multiple Sclerosis International·Justin M HonceEric Nyberg
Mar 25, 2016·BMJ Case Reports·Sharfaraz SalamAyse Turan
May 11, 2016·Neurology·Tirisham V GyangLawrence Samkoff
Jul 28, 2016·Multiple Sclerosis and Related Disorders·Julian Borchardt, Joseph R Berger
Aug 18, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Martijn T WijburgMike P Wattjes
Jun 24, 2017·Journal for Immunotherapy of Cancer·Heinz LäubliFrank Stenner-Liewen
Sep 15, 2017·Clinical Imaging·Emily BradyAndrew D Schweitzer

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Citations

Sep 21, 2019·Clinical Neuroradiology·Stefan WeidauerElke Hattingen
Nov 11, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Shi-Jun LiLi-Qun Liu

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