MRI analysis of the changes in apparent water diffusion coefficient, T(2) relaxation time, and cerebral blood flow and volume in the temporal evolution of cerebral infarction following permanent middle cerebral artery occlusion in rats

Experimental Neurology
M RudinA Sauter

Abstract

Detailed knowledge of similarities and differences between animal models and human stroke is decisive for selecting clinically effective drugs based on efficacy data obtained preclinically. Differences in the temporal evolution of stroke pathologies between animal models and man have been reported. In view of the importance of this issue for the development of neuroprotective treatments, the temporal evolution of stroke pathologies in the rat permanent middle cerebral artery occlusion (pMCAO) model has been evaluated with magnetic resonance imaging modalities under experimental conditions matching as close as possible those used in humans. Changes in the ipsilateral and contralateral cortex and striatum of cerebral blood flow (CBF) and volume (CBV), apparent diffusion coefficient (ADC), and spin-spin relaxation time (T(2)), as well as total cortical and striatal infarct volumes, calculated from CBF, ADC, and T(2) maps, were determined starting 1 h up to 216 h post-pMCAO. The temporal evolution of the MRI parameters in this rat model was similar to that observed in humans. In particular, the ADC values were decreased for more than 3 days and returned back to baseline between 4 to 8 days, to increase by day 9 only. Thus the strok...Continue Reading

References

May 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M E MoseleyP R Weinstein
Apr 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K Siesjö, F Bengtsson
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A TamuraG M Teasdale
Nov 1, 1995·Stroke; a Journal of Cerebral Circulation·K M WelchS R Levine
Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Hoehn-BerlageK A Hossmann
Jul 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S A RousselD G Gadian
Dec 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A van der ToornK Nicolay
Dec 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M Hoehn-BerlageK Yamashita
Sep 10, 1998·Stroke; a Journal of Cerebral Circulation·K J van EverdingenW P Mali
Aug 6, 1999·Stroke; a Journal of Cerebral Circulation·T Neumann-HaefelinH J Freund
Oct 8, 1999·Stroke; a Journal of Cerebral Circulation·P A BarberS M Davis
May 8, 2000·Stroke; a Journal of Cerebral Circulation·L OstergaardB R Rosen

❮ Previous
Next ❯

Citations

Mar 20, 2010·Experimental & Translational Stroke Medicine·Fabien ChauveauTae-Hee Cho
Apr 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Andre SauterMarkus Rudin
Mar 4, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Juergen BardutzkyMarc Fisher
Feb 26, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Rafael E ChaparroDavid S Warner
Nov 18, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nick M E A HaywardJukka Jolkkonen
Dec 7, 2007·Magnetic Resonance Imaging·Simona NikolovaRobert Bartha
Aug 8, 2009·International Journal of Stroke : Official Journal of the International Stroke Society·J KaurP A Barber
Jul 17, 2004·The European Journal of Neuroscience·Thomas MuegglerMarkus Rudin
Jul 18, 2008·Diabetes·Natalie YuenMartha E O'Donnell
Jun 7, 2005·Experimental Neurology·Louise van der WeerdDavid G Gadian
Sep 10, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Martha E O'DonnellSteven E Anderson
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·Shozo GotoPatricia D Hurn
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Luigi SironiElena Tremoli
Nov 3, 2007·Stroke; a Journal of Cerebral Circulation·Munehisa ShimamuraRyuichi Morishita
Oct 18, 2006·Annals of Neurology·Evelyne BeraudPatrick J Cozzone
Feb 12, 2019·Journal of Inherited Metabolic Disease·Nikolas BoyInga Harting
Jul 3, 2015·Frontiers in Psychology·Jan A F CoeberghJ D Blom
May 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shu-Wei SunSheng-Kwei Song
Oct 25, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M RauschM Rudin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Leonid GoubergritsHans-Christian Hege
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Simona NikolovaRobert Bartha
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Martin KavecRisto A Kauppinen
© 2021 Meta ULC. All rights reserved