MRI and cognition in multiple sclerosis

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
M Filippi, M A Rocca

Abstract

Magnetic resonance imaging (MRI) techniques have contributed to ameliorate the understanding of the mechanisms responsible for the accumulation of cognitive impairment in patients with multiple sclerosis. Earlier studies demonstrated a relationship of the location of T2-visible lesions in critical brain regions and atrophy of several brain compartments with the severity of cognitive impairment in these patients. More recently, the development of new postprocessing approaches and the application of quantitative MR techniques for the assessment of structural disease-related damage in the brain normal-appearing white matter and gray matter resulted in a better understanding of the factors associated with the onset and development of deficits of several cognitive domains. In addition, the use of functional MRI has disclosed that brain cortical reorganization may play a role in limiting the neuropsychological consequences of structural damage in the different stages of the disease.

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Citations

Nov 24, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Ye QiaoJames A Hamilton
May 17, 2014·Neurodegenerative Disease Management·Päivi Hämäläinen, Eija Rosti-Otajärvi
Mar 29, 2011·Neurologic Clinics·Lawrence M Samkoff, Andrew D Goodman
Dec 9, 2014·Journal of Clinical and Experimental Neuropsychology·Martina Gaia CogoValeria Isella
Sep 2, 2016·Acta Neurologica Scandinavica·P Hämäläinen, E Rosti-Otajärvi
Jul 6, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Álvaro J Cruz-GómezCristina Forn
Feb 6, 2017·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Cindy K LiebenRaymond M Hupperts
Apr 24, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Sara LlufriuMassimo Filippi
Oct 19, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Daniel OntanedaMaria Pia Amato
Feb 12, 2014·The Cochrane Database of Systematic Reviews·Eija M Rosti-Otajärvi, Päivi I Hämäläinen
Jul 17, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·F RinaldiP Gallo
Mar 27, 2018·The Open Neurology Journal·Katerina NtoskouPanagiotis Papathanasopoulos
Dec 19, 2020·Therapeutic Advances in Neurological Disorders·Thomas BergerEva Kubala Havrdová

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