MRI and PET/CT for evaluation of the pathological response to neoadjuvant chemotherapy in breast cancer: A systematic review and meta-analysis

The Breast : Official Journal of the European Society of Mastology
Huimin LiKehu Yang

Abstract

Neoadjuvant chemotherapy (NAC) has become an essential treatment for breast cancer. However, there is still no consensus on the best tool to evaluate pathological response to NAC. Two reviewers systematically searched Cochrane, PubMed, EMBASE, Web of Science, and CBM (last updated in February 2017) for eligible articles. We independently screened and selected studies that conformed to the inclusion criteria and extracted the requisite data. Pooled sensitivity, specificity, and the area under the SROC curve were calculated to estimate the diagnostic accuracy of magnetic resonance imaging (MRI) and positron emission computed tomography (PET/CT). And the relative DOR (RDOR) was used to compare accuracy for levels of the covariable. Thirteen studies involving 575 patients who underwent MRI and 618 who underwent PET/CT were included in our analysis. The pooled sensitivity and specificity of MRI were 0.88 (95% CI: 0.78-0.94) and 0.69 (95% CI: 0.51-0.83), respectively. The corresponding values for PET/CT were 0.77 (95% CI: 0.58-0.90) and 0.78 (95% CI: 0.63-0.88), respectively. The area under the SROC curve for MRI and PET/CT were 0.88 and 0.84, respectively. And the RDOR = 1.44 (95% CI, 0.46-4.47 P = 0.83). MRI had a higher sensitivit...Continue Reading

Citations

May 23, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christiane K KuhlIsabelle Bedrosian
Jul 2, 2020·Drug Design, Development and Therapy·Huan Wang, Xiaoyun Mao
Mar 8, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhenyu LiuJie Tian
Nov 23, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Dongguang WeiHuamin Wang
Nov 7, 2020·CA: a Cancer Journal for Clinicians·David R ByrdDonna M Gress
Mar 9, 2021·Biomedical Optics Express·Giulia MaffeisPaola Taroni
Jan 9, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J HeilM J Vrancken Peeters
Aug 4, 2021·Trends in Endocrinology and Metabolism : TEM·Yi LiuShuang Tang
Aug 17, 2021·Radiologic Clinics of North America·Amy M Fowler, Steve Y Cho

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