MRI and Quantitative Magnetic Susceptibility Maps of the Brain after Serial Administration of Gadobutrol: A Longitudinal Follow-up Study

Radiology
Yangsean ChoiBum-Soo Kim

Abstract

Background The relationship between administration of macrocyclic gadolinium-based contrast agents and T1-weighted signal intensity (SI) change of the globus pallidus (GP) and dentate nucleus (DN) is, to the knowledge of the authors, not known. Purpose To determine if quantitative susceptibility mapping (QSM) can detect changes in magnetic susceptibility of the GP and DN after serial administration of macrocyclic gadobutrol in patients with primary brain tumors. Materials and Methods Patients diagnosed with primary brain tumors from August 2014 to February 2019 were eligible for this single-center retrospective study. Among 501 consecutive adult patients who were given at least one administration of gadobutrol, those who were previously administered an unknown or linear gadolinium-based contrast agent were excluded. Brain MRI scans with three-dimensional gradient-recalled-echo image phase data for QSM processing were reviewed. Regions of interest were drawn on the GP and DN on the basis of semiautomatic thresholding. Univariable generalized estimation equations were used to determine the associations between MRI measures (SI on T1-weighted images and magnetic susceptibility on QSM) and number of gadobutrol doses. Potential conf...Continue Reading

References

Dec 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L JosephsonD White
Feb 3, 2007·Radiology·Elizabeth A SadowskiArjang Djamali
Mar 18, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Marc PortClaire Corot
Nov 13, 2008·Investigative Radiology·Thomas FrenzelHanns-Joachim Weinmann
Sep 6, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sung-Min GhoDong-Hyun Kim
Jul 22, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yi Wang, Tian Liu
Oct 1, 2014·Magnetic Resonance Imaging·E Mark HaackeYongquan Ye
Mar 6, 2015·Radiology·Robert J McDonaldLaurence J Eckel
Aug 17, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sina StraubFrederik B Laun
Sep 25, 2016·Journal of Magnetic Resonance Imaging : JMRI·Takuya HinodaKaori Togashi
Mar 16, 2017·Journal of Magnetic Resonance Imaging : JMRI·Yi WangMartin R Prince

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