MRI as a biomarker for mild neonatal encephalopathy

Early Human Development
Brian H Walsh, Terrie E Inder

Abstract

Historically, there has been limited neuro-imaging data acquired on infants with mild neonatal encephalopathy (NE). This likely reflects the traditional assumption that these infants had a universally good prognosis. As new evidence has emerged challenging this assumption, there has been a renewed interest in the neuro-imaging findings of these infants. To date, magnetic resonance imaging (MRI) studies in infants with mild NE have demonstrated abnormalities in 20-40% of cases suggestive that the injury occurs during the peripartum period with a predominant watershed pattern of injury. The severity of the injury on MRI in infants with mild NE varies, but includes patterns of injury that have been associated with long-term neuro-developmental impairment.

Citations

Dec 21, 2018·Archives of Disease in Childhood. Fetal and Neonatal Edition·Ujwal KariholuSudhin Thayyil
Oct 30, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Lili LiuJunya Chen
Jan 8, 2021·Pediatric Neurology·Michelle MachieLina Chalak
Jul 23, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Mark AdamsUNKNOWN Swiss National Asphyxia and Cooling Register Group
Jul 17, 2021·Neural Regeneration Research·Alice McDouallJoanne O Davidson

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