MRI-based assessment of endothelial function in mice in vivo

Pharmacological Reports : PR
Anna BarStefan Chlopicki

Abstract

While a healthy endothelium serves to maintain vascular haemostasis, a malfunctioning endothelium leads to various cardiovascular diseases, including atherothrombosis. Endothelial dysfunction is characterized by increased vascular permeability, impaired endothelium-dependent responses and various pro-inflammatory and pro-thrombotic changes in endothelial phenotype, all of which could provide the basis for an in vivo diagnosis of endothelial dysfunction. In the present review, we briefly summarize the magnetic resonance imaging (MRI)-based methods available for assessing endothelial function in animal models, especially in mice. These methods are aimed to assess biochemical phenotype using molecular imaging, endothelium-dependent responses or changes in endothelial permeability. All these approaches provide a complementary insight into the endothelial dysfunction in vivo and may offer a unique opportunity to study endothelium-based mechanisms of diseases and endothelial response to treatment.

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Citations

May 18, 2016·British Journal of Pharmacology·Andreas DaiberThomas Münzel
May 10, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Volker AdamsJosef Niebauer
Sep 1, 2015·Pharmacological Reports : PR·Stefan Chlopicki
Jul 20, 2021·Journal of Cellular Physiology·Jun ZhangZhi-Ren Zhang

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