MRI-based detection of renal artery abnormalities related to renal denervation by catheter-based radiofrequency ablation in drug resistant hypertensive patients

European Radiology
Monica SigovanLoic Boussel

Abstract

Endovascular renal denervation (RDN) using catheter-based radiofrequency (RF) ablation has emerged as a potential treatment option for drug-resistant hypertension. Its efficacy is currently under debate. We aimed to evaluate the capability of contrast-enhanced magnetic resonance imaging (MRI) to assess the effects of RDN on the renal arterial wall in patients presenting with drug-resistant hypertension. Patients were included prospectively following institutional review board approval and written informed consent. Renal arteries were imaged using a two-dimensional T1-weighted TSE sequence pre- and post-administration of a gadolinium-based contrast agent, before (D0), 2 days (D2) and 6 months (M6) after RDN. Mean enhancement of the wall (mENH) and mean wall thickness (mWT) were compared across time using an ANOVA with repeated measures and post-hoc paired t-test. Follow-up was completed for 23 patients (median age, 57 years; 16 men). The mENH at D2 (96.3 ± 36.0 %) was significantly higher than at D0 (61.1 ± 26.3%, p < 0.001) and M6 (66.1±22.7%, p < 0.001). Similarly, mWT was significantly higher at D2 (3.1 ± 0.4 m) than at D0 (2.7 ± 0.4mm, p < 0.001) and M6 (2.9 ± 0. 5 mm, p = 0.002). MRI demonstrated abnormalities of the arteri...Continue Reading

References

Mar 3, 2007·Journal of Digital Imaging·Philippe A PuechRégis Beuscart
Oct 7, 2011·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Daniel S AthertonFarrell O Mendelsohn
Nov 13, 2012·Journal of the American College of Cardiology·Benjamin KaltenbachStefan C Bertog
Dec 25, 2013·The Canadian Journal of Cardiology·Michael FroeschlMarcel Ruzicka
Apr 1, 2014·The New England Journal of Medicine·Deepak L BhattUNKNOWN SYMPLICITY HTN-3 Investigators
May 16, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Paul Bhamra-ArizaDavid W Muller
Aug 16, 2014·Journal of the American College of Cardiology·Kenichi SakakuraMichael Joner
Aug 26, 2014·Journal of the American Society of Hypertension : JASH·Murray Esler
Feb 5, 2015·Journal of the American Society of Hypertension : JASH·Murray Epstein, Eduardo de Marchena
Feb 6, 2015·Circulation. Cardiovascular Interventions·Kenichi SakakuraRenu Virmani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.