MRI-based high-dimensional hippocampal mapping in mesial temporal lobe epilepsy

Brain : a Journal of Neurology
R Edward HoganJ G Csernansky

Abstract

MRI-based evaluation of the hippocampus is important in the assessment and treatment of patients with mesial temporal lobe epilepsy (MTLE). Using MRI-based large-deformation high-dimensional mapping (HDM-LD), which allows structural evaluation of regions of the hippocampus, we document the HDM-LD-defined pattern of hippocampal deformation in MTLE patients compared with matched controls. In 30 subjects with MTLE and confirmed medial temporal lobe sclerosis (MTS), we performed measurements of intracranial area, brain parenchymal volume and deformation-based hippocampal segmentations, and then grouped patients into right and left MTS groups (resulting in 15 subjects in each group). Using HDM-LD techniques, we compared the right and left MTS groups with a group of 15 matched controls. Analysis included both the MTS and contralateral hippocampi, and covariance for changes in brain parenchymal volume. Final results were interpreted using a segmentation showing normal hippocampal surface subfield anatomy. Comparing the MTS groups with controls, after covarying with brain parenchymal volume, the MTS hippocampi showed significant volume loss (P < 0.0001), contralateral hippocampi showed no significant volume loss. HDM-LD techniques show...Continue Reading

Citations

Jan 19, 2006·Epilepsia·Tayo O OyegbileBruce P Hermann
Jun 27, 2009·Stereotactic and Functional Neurosurgery·Hiroyuki OyaMatthew A Howard
Jun 19, 2014·BMC Neurology·Hila GoldbergRobert Zivadinov
Nov 1, 2015·NeuroImage·Andrea ChincariniUNKNOWN Alzheimer's Disease Neuroimaging Initiative
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Aug 2, 2005·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Robert Gardner, R Edward Hogan
May 14, 2009·Hippocampus·Sandhitsu R DasPaul A Yushkevich
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Jul 11, 2006·Hippocampus·Nitin GogtayPaul M Thompson
Dec 23, 2014·IEEE Transactions on Medical Imaging·Jaeil KimJinah Park
Jun 20, 2014·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·R Edward HoganLuigi Maccotta
Aug 1, 2015·Cerebral Cortex·Boris C BernhardtAndrea Bernasconi
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May 8, 2020·Annals of Neurology·Tjardo S PostmaMarian Galovic
Nov 6, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ying R LiuViviane Bouilleret

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