MRI-based low dose-rate brachytherapy experience in locally advanced cervical cancer patients initially treated by concomitant chemoradiotherapy

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
C Haie-MederNicolas Magné

Abstract

To retrospectively assess the physics contributions and the clinical outcome with preliminary 3D MRI-guided low dose-rate (LDR) intracavitary brachytherapy (BT) experience in locally advanced cervical cancer patients. Eighty-four patients with primary locally advanced cervical carcinoma were analyzed. The median tumoral cervical volume was 48.0 cc (range 1-468 cc). Twenty-four patients (53%) had histological and/or radiological pelvic involvement. After pelvic+/-paraaortic concomitant chemoradiation, a LDR BT boost was delivered to a 3D MRI-based clinical target volume taking into account dose volume constraints for critical organs and optimization of target volume coverage. With a median follow-up of 53 months (range 31-79 months), the 4-year overall survival and disease-free survival rates were 57 (95%CI, 43-69) and 52% (95%CI, 40-64), respectively. Adding EBRT and LDR using EQD2 model, the median D(100) and D(90) for the IR-CTV were 56.5 Gy(alpha/beta10) (range 37-83 Gy(alpha/beta10)) and 69 Gy(alpha/beta10) (range 52-113 Gy(alpha/beta10)), respectively. For HR-CTV, the median D(100) and D(90) were 67 Gy(alpha/beta10) (range 47-119 Gy(alpha/beta10)) and 79 Gy(alpha/beta10) (range 53-122 Gy(alpha/beta10)), respectively. Thirt...Continue Reading

References

Jun 2, 1998·International Journal of Radiation Oncology, Biology, Physics·C A PerezM A Lockett
Aug 5, 1999·Hematology/oncology Clinics of North America·M D Logsdon, P J Eifel
Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·A Katz, P J Eifel
Feb 13, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C FellnerA Wambersie
May 23, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R PötterUNKNOWN EVA(endovascular) GEC (Groupe Europeen de Curietherapie) ESTRO (European Society for Therapeutic Radiation Oncology) Working
Mar 15, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christine Haie-MederUNKNOWN Gynaecological (GYN) GEC-ESTRO Working Group
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Christian KirisitsDietmar Georg
Aug 16, 2005·International Journal of Radiation Oncology, Biology, Physics·Beth EricksonJean Owen
May 29, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Richard PötterChristian Kirisits
Nov 27, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marisol De BrabandereErik Van Limbergen
Jan 15, 2008·International Journal of Radiation Oncology, Biology, Physics·Jacob C LindegaardJohn Gelineck
May 23, 2008·International Journal of Radiation Oncology, Biology, Physics·Dietmar GeorgRichard Pötter
Sep 9, 2008·International Journal of Radiation Oncology, Biology, Physics·Cyrus ChargariChristine Haie-Meder
Dec 23, 2008·International Journal of Radiation Oncology, Biology, Physics·Daniel ZwahlenMichael Milosevic
Jul 10, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christine Haie-MederNicolas Magné
Aug 15, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Johannes C A DimopoulosChristian Kirisits

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Citations

Oct 12, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·K KirchheinerW Dörr
Dec 21, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M P SchmidC Kirisits
Jan 25, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M P SchmidR Pötter
May 25, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·P GeorgW Dörr
Oct 19, 2012·Radiology and Oncology·Primoz PetricJohannes Carl Athanasios Dimopoulos
Apr 26, 2012·Medical Oncology·Orit Kaidar-PersonAbraham Kuten
Nov 7, 2012·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Agnieszka Zolciak-SiwinskaWojciech Michalski
Jul 28, 2012·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J ConibearP J Hoskin
Aug 22, 2013·Acta Oncologica·Jacob Christian LindegaardKari Tanderup
Mar 10, 2015·Gynecologic Oncology·Akila N Viswanathan, Beth A Erickson
May 29, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Claire Charra-BrunaudDidier Peiffert
Mar 6, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A PaumierC Haie-Meder
Mar 7, 2012·Brachytherapy·Jacob Christian Lindegaard, Kari Tanderup
Jun 15, 2011·International Journal of Radiation Oncology, Biology, Physics·Christel N NomdenIna Maria Jürgenliemk-Schulz
Oct 5, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kari TanderupChristian Kirisits
Oct 16, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Antonin LevyChristine Haie-Meder
Sep 20, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Maximilian P SchmidRichard Pötter
Jul 9, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Brita Singers SørensenLars Hjorth Præstegaard
May 4, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christel N NomdenIna Maria Jürgenliemk-Schulz
Oct 17, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicole NesvacilChristian Kirisits
Feb 3, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Johannes C A DimopoulosRichard Pötter
Oct 4, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christine Haie-MederRichard Pötter
Sep 20, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lars FokdalJacob Christian Lindegaard
May 21, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Agnieszka Zolciak-SiwinskaKrzysztof Bujko
Oct 12, 2014·International Journal of Radiation Oncology, Biology, Physics·Akila N ViswanathanWalter Bosch
Oct 14, 2014·Journal of Gynecologic Oncology·Kailash NarayanSrinivas Kondalsamy Chennakesavan
Jul 22, 2014·Journal of Gynecologic Oncology·Kailash NarayanSrinivas Kondalsamy-Chennakesavan
May 10, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ivone RibeiroErik Van Limbergen
Feb 13, 2016·International Journal of Radiation Oncology, Biology, Physics·Richard PötterNicole Nesvacil
Feb 6, 2018·Radiation Oncology·Sophie EspenelNicolas Magné
Dec 3, 2016·Radiology and Oncology·Primoz PetricBarbara Segedin
May 22, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Umesh MahantshettyNapapat Amornwichet

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