MRI-based quantification of outflow boundary conditions for computational fluid dynamics of stenosed human carotid arteries

Journal of Biomechanics
Harald C GroenJolanda J Wentzel

Abstract

Accurate assessment of wall shear stress (WSS) is vital for studies on the pathogenesis of atherosclerosis. WSS distributions can be obtained by computational fluid dynamics (CFD) using patient-specific geometries and flow measurements. If patient-specific flow measurements are unavailable, in- and outflow have to be estimated, for instance by using Murray's Law. It is currently unknown to what extent this law holds for carotid bifurcations, especially in cases where stenoses are involved. We performed flow measurements in the carotid bifurcation using phase-contrast MRI in patients with varying degrees of stenosis. An empirical relation between outflow and degree of area stenosis was determined and the outflow measurements were compared to estimations based on Murray's Law. Furthermore, the influence of outflow conditions on the WSS distribution was studied. For bifurcations with an area stenosis smaller than 65%, the outflow ratio of the internal carotid artery (ICA) to the common carotid artery (CCA) was 0.62+/-0.12 while the outflow ratio of the external carotid artery (ECA) was 0.35+/-0.13. If the area stenosis was larger than 65%, the flow to the ICA decreased linearly to zero at 100% area stenosis. The empirical relation...Continue Reading

References

Feb 1, 1990·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·M TarnawskiM A Smith
Oct 1, 1981·The Journal of General Physiology·T F Sherman
Nov 3, 1998·Cardiovascular Research·S K SamijoA P Hoeks
Sep 4, 1999·Physiological Measurement·D W HoldsworthB K Rutt
Dec 11, 1999·JAMA : the Journal of the American Medical Association·A M MalekS Izumo
May 15, 2002·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Joachim LotzMichael Galanski
Jun 12, 2004·IEEE Transactions on Medical Imaging·Luca Antiga, David A Steinman
Jul 16, 2004·Physiological Measurement·Ian MarshallKarolina Wartolowska
Jan 29, 2005·Annals of Biomedical Engineering·Ghassan S KassabHans Gregersen
Mar 5, 2005·Stroke; a Journal of Cerebral Circulation·Michiel L BotsJacqueline C M Witteman
May 12, 2005·Physiological Measurement·Matthew D FordDavid A Steinman
May 25, 2005·Annals of Biomedical Engineering·Taewon SeoAbdul I Barakat
Mar 1, 1926·Proceedings of the National Academy of Sciences of the United States of America·C D Murray
Jul 7, 2007·Stroke; a Journal of Cerebral Circulation·Harald C GroenJolanda J Wentzel
Jan 29, 2008·Current Drug Targets·Godfrey S GetzCatherine A Reardon
Sep 4, 2009·European Journal of Epidemiology·Albert HofmanJacqueline C M Witteman

❮ Previous
Next ❯

Citations

Feb 1, 2012·Computer Methods in Biomechanics and Biomedical Engineering·Yu ZhangYi Qian
Nov 22, 2013·Nihon Hoshasen Gijutsu Gakkai zasshi·Tatsunori SahoItsuo Yuda
Feb 13, 2014·Current Atherosclerosis Reports·Young I ChoRobert S Rosenson
Jan 25, 2013·International Journal for Numerical Methods in Biomedical Engineering·Jingliang DongJiyuan Tu
Jan 25, 2014·International Journal for Numerical Methods in Biomedical Engineering·Jun-Mei ZhangRu San Tan
May 9, 2014·IEEE Journal of Biomedical and Health Informatics·Nicolas AristokleousAndreas S Anayiotos
Feb 15, 2013·IEEE Transactions on Medical Imaging·Alejandro F FrangiDana Brooks
Dec 1, 2015·Journal of Biomechanics·Bruno GuerciottiMaurizio Domanin
Apr 26, 2016·Journal of Vascular Surgery·Maurizio Domanin, Christian Vergara
May 12, 2016·Computer Methods in Biomechanics and Biomedical Engineering·Muhammad JamilChoon Hwai Yap
Aug 20, 2016·Biomechanics and Modeling in Mechanobiology·Bruno GuerciottiRoberto Scrofani
May 3, 2013·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Chang-Joon LeeYi Qian
Jan 18, 2017·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Sheau Fung SiaYu Chen
Sep 29, 2011·Korean Circulation Journal·Byoung-Kwon Lee
Mar 16, 2019·AJNR. American Journal of Neuroradiology·K C J CompagneUNKNOWN MR CLEAN investigators
Apr 3, 2019·Cardiovascular Engineering and Technology·Viviana ManciniKristian Valen-Sendstad
Jul 10, 2018·Biomechanics and Modeling in Mechanobiology·Pengcheng XuWenhua Huang
Feb 16, 2021·International Journal for Numerical Methods in Biomedical Engineering·Silvia PozziChristian Vergara
Apr 21, 2021·Journal of Biomechanical Engineering·Lorenzo BennatiRenato Casana
May 15, 2021·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Jian LiuYu Zhang
Aug 3, 2021·International Journal for Numerical Methods in Biomedical Engineering·Elisa FevolaPiero Triverio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.