MRI-based synthetic CT generation using semantic random forest with iterative refinement

Physics in Medicine and Biology
Yang LeiXiaofeng Yang

Abstract

Target delineation for radiation therapy treatment planning often benefits from magnetic resonance imaging (MRI) in addition to x-ray computed tomography (CT) due to MRI's superior soft tissue contrast. MRI-based treatment planning could reduce systematic MR-CT co-registration errors, medical cost, radiation exposure, and simplify clinical workflow. However, MRI-only based treatment planning is not widely used to date because treatment-planning systems rely on the electron density information provided by CTs to calculate dose. Additionally, air and bone regions are difficult to separategiven their similar intensities in MR imaging. The purpose of this work is to develop a learning-based method to generate patient-specific synthetic CT (sCT) from a routine anatomical MRI for use in MRI-only radiotherapy treatment planning. An auto-context model with patch-based anatomical features was integrated into a classification random forest to generate and improve semantic information. The semantic information along with anatomical features was then used to train a series of regression random forests based on the auto-context model. After training, the sCT of a new MRI can be generated by feeding anatomical features extracted from the MRI...Continue Reading

References

Sep 19, 2006·The British Journal of Radiology·V S Khoo, D L Joon
Apr 10, 2010·IEEE Transactions on Medical Imaging·Nicholas J TustisonJames C Gee
Apr 13, 2010·International Journal of Radiation Oncology, Biology, Physics·Kenneth UlinJoel M Cherlow
Aug 21, 2010·IEEE Transactions on Pattern Analysis and Machine Intelligence·Zhuowen Tu, Xiang Bai
Jul 23, 2011·Medical Physics·Adam JohanssonTufve Nyholm
Jul 10, 2012·Magnetic Resonance Imaging·Uulke A van der HeidePhilippe Lambin
Nov 7, 2012·Medical Physics·Slobodan Devic
Jun 14, 2013·Journal of the American Medical Informatics Association : JAMIA·Xiaofeng Yang, Baowei Fei
Oct 17, 2014·Physics in Medicine and Biology·Madhu Sudhan Reddy GudurRuijiang Li
Nov 14, 2014·Physics in Medicine and Biology·Jens M EdmundDaniel Andreasen
Dec 3, 2014·International Journal of Radiation Oncology, Biology, Physics·Joshua KimIndrin J Chetty
Jan 8, 2015·Physics in Medicine and Biology·J SjölundH Knutsson
Feb 14, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jorge CabelloSibylle I Ziegler
Aug 5, 2015·IEEE Transactions on Medical Imaging·Tri HuynhUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 24, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Angel Torrado-CarvajalNorberto Malpica
Oct 29, 2015·Physics in Medicine and Biology·Maria A Schmidt, Geoffrey S Payne
Mar 5, 2016·Journal of Cheminformatics·P B JayarajU C A Jaleel
Aug 5, 2016·Medical Physics·Daniel AndreasenJens M Edmund
Jan 28, 2017·Radiation Oncology·Jens M Edmund, Tufve Nyholm
Nov 28, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Souha AouadiNoora Al-Hammadi
Dec 20, 2017·International Journal of Radiation Oncology, Biology, Physics·Emily JohnstoneRichard Speight
Jul 12, 2018·IEEE Transactions on Bio-medical Engineering·Dong NieDinggang Shen
Aug 16, 2018·Physics in Medicine and Biology·Matteo MasperoCornelis A T van den Berg
Oct 20, 2018·International Journal of Radiation Oncology, Biology, Physics·Axel LargentRenaud de Crevoisier
Feb 1, 2017·Proceedings of SPIE·Xiaofeng YangTian Liu

❮ Previous
Next ❯

Citations

Oct 15, 2020·Medical Physics·Xianjin DaiXiaofeng Yang
Feb 18, 2021·Physics in Medicine and Biology·Ruirui LiuXiaofeng Yang
Feb 20, 2021·International Journal of Particle Therapy·Tonghe WangXiaofeng Yang
May 13, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Ana Barragán-MonteroJohn A Lee
May 17, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Yabo FuXiaofeng Yang
Jul 8, 2021·Journal of Applied Clinical Medical Physics·Shadab MominXiaofeng Yang
Oct 30, 2020·Physics in Medicine and Biology·Haley A MassaAlan B McMillan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Yang LeiX Yang
Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists
Ghazal Shafai-ErfaniXiaofeng Yang
© 2022 Meta ULC. All rights reserved