Abstract
Background and Purpose: Non-traumatic intracerebral hemorrhage (ICH) in younger population is a relatively rare event but is associated with considerable mortality and poor functional outcome. Imaging plays a crucial role in determining the underlying cause and guide treatment of ICH. In up to 41% of patients in prior studies, the underlying cause remained elusive. However, the usage of MRI as part of diagnostic work-up was scanty. We aimed to analyze MRI findings of ICH in younger patients and assess specificity and sensitivity of MRI in detecting structural or local underlying causes of ICH. Methods: We included patients aged 15-49 years with first-ever ICH identified from a prospective hospital discharge registry, 2000-2010. All study patients underwent MRI within 3 months of ICH. Imaging data was analyzed by a senior neuroradiologist blinded to final clinical diagnosis. We calculated the diagnostic accuracy of MRI in detecting structural/local underlying causes. Results: Of our 116 patients (median age, 39; 67% males), structural/local causes were the leading causes of ICH (50.0%), and of these, bleeding cavernomas (23.3%) were the most frequent followed by arteriovenous malformations (12.9%), cerebral venous thrombosis (CV...Continue Reading
References
Jan 1, 1990·Neuroradiology·U GrzyskaH Zeumer
Mar 1, 1990·Stroke; a Journal of Cerebral Circulation·H BevanW Bradley
Feb 1, 1990·Stroke; a Journal of Cerebral Circulation·G J HankeyR J Sellar
May 1, 1987·Archives of Neurology·G J ToffolH P Adams
Aug 1, 1996·Stroke; a Journal of Cerebral Circulation·R U KothariJ Khoury
Feb 5, 1999·Stroke; a Journal of Cerebral Circulation·H J CloftJ E Dion
Mar 6, 1999·Stroke; a Journal of Cerebral Circulation·J L Ruíz-SandovalF Barinagarrementeria
Feb 20, 2003·Neurosurgery·E Thomas ChappellMatthew C Good
Feb 26, 2003·Clinical Chemistry·Carsten StephanKlaus Jung
Apr 5, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S-L LaiS-P Hsu
Sep 27, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·A AwadaS Al Rajeh
Aug 25, 2010·Cerebrovascular Diseases·Christine A C WijmanNeil Schwartz
Nov 24, 2011·Neurosurgery Clinics of North America·Mahmud Mossa-BashaDheeraj Gandhi
Apr 25, 2012·Clinical Neurology and Neurosurgery·Matthew A KirkmanHiren C Patel
Aug 4, 2012·Stroke; a Journal of Cerebral Circulation·Atte MeretojaTurgut Tatlisumak
Oct 17, 2013·Journal of the Neurological Sciences·Jayantee KalitaUsha K Misra
Oct 30, 2013·Journal of Cerebrovascular and Endovascular Neurosurgery·Gyeong O GoIn Sung Park
Mar 1, 2014·Stroke; a Journal of Cerebral Circulation·Nathalie E SynhaeveFrank-Erik de Leeuw
Jun 21, 2014·Stroke; a Journal of Cerebral Circulation·Riku-Jaakko KoivunenJukka Putaala
Aug 21, 2014·Journal of Neurology·Loes Ca Rutten-JacobsFrank-Erik de Leeuw
Aug 22, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R-J KoivunenJ Putaala
Feb 24, 2015·AJNR. American Journal of Neuroradiology·S ShamsM Kristoffersen-Wiberg
Jan 1, 1994·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·J L FuhL S Lee
Nov 11, 2015·BMJ : British Medical Journal·Charlotte J J van AschUNKNOWN DIAGRAM Investigators
Mar 10, 2018·Nature Reviews. Neurology·Turgut TatlisumakJukka Putaala
Mar 21, 2018·Radiology·Sven HallerFrederik Barkhof
Oct 31, 2019·Stroke; a Journal of Cerebral Circulation·William J PowersDavid L Tirschwell