MRI Contrast Agents Based on Conjugated Polyelectrolytes and Dendritic Polymers

Macromolecular Rapid Communications
Manyu JinJingwei Xu

Abstract

Three complexes of gadolinium-based on dentritic molecules are reported as magnetic resonance imaging (MRI) contrast agents. Their ligands feature four carboxylate groups, which contribute to good water solubility and a strong combination with metal ions. As a new attempt, coupling polymerization is carried out to make a combination of conjugated polyelectrolytes and dendrimers for MRI contrast agents. For comparison, mononuclear and binuclear complexes are also reported. The investigation suggests that the contrast agent with the newly designed macromolecular skeleton provides higher longitudinal relaxivity value (36.2 mm -1 s-1 ) and more visible enhancement in in vivo and in vitro MR images than the small molecular ones. In addition, extremely low cytotoxicity and main clearance via hepatobiliary are confirmed, which reduces the deterioration of chronic kidney disease. All the results indicate that these three complexes are generally applicable as promising clinical contrast agents.

References

Dec 24, 2005·Chemical Communications : Chem Comm·Youfu ZhouXintao Wu
Apr 18, 2008·International Urology and Nephrology·Sandip K SaxenaDimitrios Oreopoulos
Jun 10, 2008·Molecular Pharmaceutics·C Andrew BoswellMartin W Brechbiel
Mar 2, 2010·Angewandte Chemie·Luca FrullanoPeter Caravan
Oct 31, 2014·Contrast Media & Molecular Imaging·Dina V HingoraniMark D Pagel
Jun 9, 2015·Chemical Communications : Chem Comm·Jonathan D FreedmanMark W Grinstaff
Nov 21, 2015·Journal of the American Chemical Society·Eric M GalePeter Caravan
Dec 21, 2017·ACS Applied Materials & Interfaces·Qiang LuoQiyong Gong
Apr 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chunhua GuoZhongwei Gu
Nov 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yi CaoRenjun Pei
Jun 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Simin ZhangLixin Wu

❮ Previous
Next ❯

Citations

Jul 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tingting ZhouLixin Wu
Sep 20, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Haonan LiKui Luo
Sep 10, 2019·Inorganic Chemistry·Maleotane NdiayeFrançoise Chuburu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.