MRI correlates of cognitive decline in CADASIL: a 7-year follow-up study

Neurology
Michael K LiemJeroen van der Grond

Abstract

Cognitive decline is one of the clinical hallmarks of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a cerebrovascular disease caused by NOTCH3 mutations. In this 7-year follow-up study, we aimed to determine whether there are associations between the different radiologic hallmarks in CADASIL and decline in specific cognitive domains. Twenty-five NOTCH3 mutation carriers and 13 controls had standardized neuropsychological testing and MRI examinations at baseline and after a follow-up of 7 years. To identify longitudinal associations between MRI abnormalities and cognitive decline, correlation analysis was used. At follow-up, mutation carriers showed a decline in global cognitive function (CAMCOG, p < 0.01) and in the cognitive domains language, memory, and executive function, compared to controls. Cognitive decline, especially executive dysfunction, was associated with increase in lacunar infarcts, microbleeds, and ventricular volume. In contrast, WMHs and brain atrophy were not associated with cognitive decline. Increase in lacunar infarcts, microbleeds, and ventricular volume, but not white matter lesions or atrophy, are associated with cognitive decline in the process of...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Nov 18, 1998·Annals of Neurology·M DichgansT Gasser
May 15, 2004·Stroke; a Journal of Cerebral Circulation·Kaarina AmberlaMatti Viitanen
Jul 28, 2004·NeuroImage·Paul M ThompsonArthur W Toga
Jul 30, 2004·Brain : a Journal of Neurology·David J WerringH Rolf Jäger
Nov 5, 2005·Stroke; a Journal of Cerebral Circulation·Markus HoltmannspötterMartin Dichgans
Jan 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·F BuffonH Chabriat
Mar 1, 2006·Neurobiology of Aging·Owen T CarmichaelJames T Becker
May 24, 2006·Neurology·R A CharltonH S Markus
Sep 30, 2006·Stroke; a Journal of Cerebral Circulation·Christian OpherkMartin Dichgans
Feb 3, 2007·Stroke; a Journal of Cerebral Circulation·Michael K LiemSaskia A J Lesnik Oberstein
May 19, 2007·Stroke; a Journal of Cerebral Circulation·Julie A Schneider

❮ Previous
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Citations

Nov 9, 2010·Current Neurology and Neuroscience Reports·James F Meschia
May 29, 2012·Translational Stroke Research·Xiaojie ZhangMichael M Wang
Jun 2, 2011·Nature Reviews. Neurology·James F MeschiaStephen S Rich
May 25, 2013·Journal of Radiology Case Reports·Ajeet Gordhan, Brian K Hudson
Dec 22, 2015·Biochimica Et Biophysica Acta·Gargi BanerjeeDavid J Werring
Mar 8, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Gabriella SpinicciNicola Carboni
Sep 21, 2010·Journal of the Neurological Sciences·Margherita Cavalieri, Reinhold Schmidt
Jun 4, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Philip BenjaminHugh S Markus
Apr 23, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Reinhold SchmidtMarisa Loitfelder
Jan 6, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Bhavini Patel, Hugh S Markus
Sep 29, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Toby B Cumming, Amy Brodtmann
Nov 25, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Chris MoranVelandai K Srikanth
Nov 25, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Wai Kwong TangKa Sing Wong
Nov 21, 2012·Developmental Medicine and Child Neurology·Cyril GitiauxBrigitte Bader-Meunier
Oct 9, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Matthew Schrag, David M Greer
Jun 13, 2014·Journal of Neurology·Jee Hyun HamPhil Hyu Lee
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Eric JouventHugues Chabriat
Jul 25, 2012·Experimental Gerontology·Wiesje M Van der Flier, Charlotte Cordonnier
Jun 22, 2012·Journal of the Neurological Sciences·Andreas Charidimou, David J Werring
Jun 26, 2012·Journal of the Neurological Sciences·Stephan SeilerReinhold Schmidt
Feb 9, 2017·Journal of Hypertension·Renske UiterwijkRobert J van Oostenbrugge
Jul 15, 2011·Arquivos de neuro-psiquiatria·Júlio César Vasconcelos da SilvaCharles André
Mar 2, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Breda CullenKeith W Muir
Jun 3, 2018·Journal of the American Heart Association·Jinbiao ZhangZhenguang Li
Dec 15, 2010·Stroke; a Journal of Cerebral Circulation·Arani NitkunanHugh S Markus
Oct 29, 2011·Stroke; a Journal of Cerebral Circulation·Philip B Gorelick
Jan 17, 2013·Stroke; a Journal of Cerebral Circulation·Bhavini PatelHugh S Markus
Feb 6, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yifeng LingHugues Chabriat
Nov 28, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Shangran QiuVijaya B Kolachalama
Nov 21, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·François De GuioEric Jouvent
Oct 13, 2018·Journal of Neurology·Anna BersanoUNKNOWN Lombardia GENS-group
Jan 19, 2019·Annals of Clinical and Translational Neurology·Gido GravesteijnSaskia A J Lesnik Oberstein
Nov 16, 2016·Annals of Clinical and Translational Neurology·Julie W RuttenSaskia A J Lesnik Oberstein
Jan 1, 2010·Dementia & Neuropsychologia·Silvia Di Legge, Vladimir Hachinski
Jul 1, 2012·Dementia & Neuropsychologia·Julio Cesar Vasconcelos da SilvaEliasz Engelhardt
Nov 23, 2019·Stroke; a Journal of Cerebral Circulation·Eric JouventHugues Chabriat

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