MRI-derived bone porosity index correlates to bone composition and mechanical stiffness.

Bone Reports
Abigail L HongChamith S Rajapakse

Abstract

The MRI-derived porosity index (PI) is a non-invasively obtained biomarker based on an ultrashort echo time sequence that images both bound and pore water protons in bone, corresponding to water bound to organic collagenous matrix and freely moving water, respectively. This measure is known to strongly correlate with the actual volumetric cortical bone porosity. However, it is unknown whether PI may also be able to directly quantify bone organic composition and/or mechanical properties. We investigated this in human cadaveric tibiae by comparing PI values to near infrared spectral imaging (NIRSI) compositional data and mechanical compression data. Data were obtained from a cohort of eighteen tibiae from male and female donors with a mean ± SD age of 70 ± 21 years. Biomechanical stiffness in compression and NIRSI-derived collagen and bound water content all had significant inverse correlations with PI (r = -0.79, -0.73, and -0.95 and p = 0.002, 0.007, and <0.001, respectively). The MRI-derived bone PI alone was a moderate predictor of bone stiffness (R 2  = 0.63, p = 0.002), and multivariate analyses showed that neither cortical bone cross-sectional area nor NIRSI values improved bone stiffness prediction compared to PI alone. H...Continue Reading

Citations

Sep 30, 2020·Seminars in Musculoskeletal Radiology·Saeed JerbanJiang Du
Oct 20, 2020·Frontiers in Endocrinology·Ya-Jun MaJiang Du
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·William QueridoNancy Pleshko

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