MRI-Derived Restriction Spectrum Imaging Cellularity Index is Associated with High Grade Prostate Cancer on Radical Prostatectomy Specimens

Frontiers in Oncology
Michael A LissDavid S Karow

Abstract

We evaluate a novel magnetic resonance imaging (MRI) technique to improve detection of aggressive prostate cancer (PCa). We performed a retrospective analysis of pre-surgical prostate MRI scans using an advanced diffusion-weighted imaging technique called restriction spectrum imaging (RSI), which can be presented as a normalized z-score statistic. Scans were acquired prior to radical prostatectomy. Prostatectomy specimens were processed using whole-mount sectioning and regions of interest (ROIs) were drawn around individual PCa tumors. Corresponding ROIs were drawn on the MRI imaging and paired with ROIs in regions with no pathology. RSI z-score and conventional apparent diffusion coefficient (ADC) values were recorded for each ROI. Paired t-test, ANOVA, and logistic regression analyses were performed. We evaluated 28 patients with 64 ROIs (28 benign and 36 PCa). The mean difference in RSI z-score (PCa ROI-Benign ROI) was 2.17 (SE = 0.11; p < 0.001) and in ADC was 551 mm(2)/s (SE = 80 mm(2)/s; paired t-test, p < 0.001). The differences in the means among all groups (benign, primary Gleason 3, and primary Gleason 4) was significant for both RSI z-score (F 3,64 = 97.7, p < 0.001) and ADC (F 3,64 = 13.9, p < 0.001). A t-test was p...Continue Reading

Associated Clinical Trials

References

Jun 10, 2004·JAMA : the Journal of the American Medical Association·Jan-Erik JohanssonHans-Olov Adami
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laurence KlotzAndrew Loblaw
Jan 21, 2014·European Urology·Stacy LoebRuth Etzioni
May 23, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Olivio F DonatiOguz Akin

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Citations

Aug 24, 2016·Cell Death Discovery·P RuggeriA R Mackay
Jan 13, 2016·Prostate Cancer and Prostatic Diseases·K C McCammackD S Karow
Mar 11, 2016·Cell Death & Disease·P RuggeriA R Mackay
Apr 5, 2016·Urologic Oncology·Ely R FelkerLeonard S Marks
Feb 26, 2016·Abdominal Radiology·Kevin C McCammackDavid S Karow
Aug 17, 2016·Journal of Magnetic Resonance Imaging : JMRI·Ryan L BrunsingDavid S Karow
May 1, 2019·AJR. American Journal of Roentgenology·Ely R FelkerLeonard S Marks
May 18, 2016·Topics in Magnetic Resonance Imaging : TMRI·Andreas WibmerHebert A Vargas
Apr 6, 2020·Abdominal Radiology·Aritrick ChatterjeeAytekin Oto
Jun 3, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ghiam YaminDavid S Karow

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Methods Mentioned

BETA
biopsy
PCA
dissection
imaging techniques

Software Mentioned

SPSS
RSI
ANVOA

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