MRI findings in children with congenital cytomegalovirus infection retrospectively diagnosed with dried umbilical cord.

Neuroradiology
Hiroyuki KidokoroYoshinori Ito

Abstract

Brain MRI provides important information about suspected congenital CMV infection in neonatally underdiagnosed children. This study aimed to describe MRI findings in children in whom congenital CMV infection was not suspected during the neonatal period and was proven retrospectively. We enrolled 31 children referred to the pediatric neurology clinic with neurological symptoms who were proven to have congenital CMV infection based on dried umbilical cord samples. Upon diagnosis, MR and CT images were assessed using the van der Knaap scoring system integrated with additional variables. Two investigators independently assessed all images. The age at diagnosis was < 12 months in 14, 12-24 months in 11, and > 24 months in 6 patients. The initial symptom triggering clinic referral was delayed development in 22, seizure in 5, deafness in 3, and hemiplegia in 1 patient. Of the 31 children, 30 had a white matter (WM) abnormality predominant in the deep WM of the parietal lobe (n = 25). Anterior temporal lesions were observed in 21 children. Cortical lesions were observed in 7 children, suggestive of polymicrogyria. No child had cerebellar or brainstem abnormalities. Brain CT was performed in 22 of 31 children, and 11 showed punctate cer...Continue Reading

References

Mar 5, 1992·The New England Journal of Medicine·M D Yow, G J Demmler
May 1, 1971·The Journal of Infectious Diseases·J B Hanshaw
Jul 7, 2005·The Pediatric Infectious Disease Journal·Akira SuzukiHidekazu Nishimura
May 2, 2006·Pediatric Neurology·Syuzo IkedaHiroyuki Moriuchi
Sep 25, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Declan O'RourkeStephanie Ryan
Apr 15, 2010·JAMA : the Journal of the American Medical Association·Suresh B BoppanaUNKNOWN National Institute on Deafness and Other Communication Disorders CMV and Hearing Multicenter Screening (CHIMES) Study
Mar 5, 2015·The New England Journal of Medicine·David W KimberlinUNKNOWN National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
Mar 18, 2016·European Radiology·Mieke M CannieJacques C Jani
Feb 27, 2017·The Journal of Pediatrics·Shannon A RossUNKNOWN CMV and Hearing Multicenter Screening (CHIMES) Study Group
Sep 11, 2018·The Pediatric Infectious Disease Journal·Isabel Vives-OñósUNKNOWN REDICCMV Study Group
Sep 18, 2018·The Pediatric Infectious Disease Journal·Antonietta GiannattasioFrancesco Raimondi
Jan 7, 2019·Pediatric Radiology·Miguel Quintas-Neves, João Paulo Soares-Fernandes
Aug 23, 2019·Chinese Medical Journal·Xin-Yan Zhang, Feng Fang

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