MRI for detection of hepatocellular carcinoma: comparison of mangafodipir trisodium and gadopentetate dimeglumine contrast agents

AJR. American Journal of Roentgenology
Ji Hyun YoukChong Soo Kim

Abstract

The purpose of our study was to compare the performance of mangafodipir trisodium (Mn-DPDP)-enhanced and dynamic gadopentetate dimeglumine-enhanced MRI for the detection of hepatocellular carcinoma. Forty-six patients with 96 hepatocellular carcinomas underwent Mn-DPDP- and gadopentetate dimeglumine-enhanced MRI. The MRI examination included unenhanced T2-weighted turbo spin-echo and T1-weighted 2D fast low-angle shot (FLASH) sequences and a 3D FLASH sequence after the administration of gadopentetate dimeglumine and Mn-DPDP. Two observers reviewed three sets of images: a set of gadopentetate dimeglumine-enhanced MR images, a set of Mn-DPDP-enhanced MR images, and a combination of the gadopentetate dimeglumine and Mn-DPDP sets. Using receiver operating characteristic (ROC) analysis, imaging sets were compared for diagnostic accuracy and sensitivity. The area under the ROC curve (A(z)) was 0.942 for the gadopentetate dimeglumine-Mn-DPDP set, 0.932 for the gadopentetate dimeglumine set, and 0.877 for the Mn-DPDP set (p < 0.05). The mean sensitivity was greater for the gadopentetate dimeglumine set than for the Mn-DPDP set (87.5% vs 72.4%; p < 0.05). The false-negative rate of the Mn-DPDP set was statistically greater than that of ...Continue Reading

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Citations

Aug 24, 2007·AJR. American Journal of Roentgenology·Thomas C LauensteinDiego R Martin
Apr 2, 2017·Clinical Therapeutics·Akihiro NishieHiroshi Honda
Mar 14, 2007·Journal of Magnetic Resonance Imaging : JMRI·James F Glockner
May 19, 2007·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Christoph J ZechStefan O Schoenberg
Dec 17, 2008·Expert Review of Gastroenterology & Hepatology·Riccardo LencioniDania Cioni
Feb 16, 2021·Clinics in Perinatology·Howard M KatzensteinRenee Gresh

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