MRI in the differential diagnosis of primary architectural distortion detected by mammography

Diagnostic and Interventional Radiology : Official Journal of the Turkish Society of Radiology
Lifang SiTao Jiang

Abstract

We aimed to evaluate the diagnostic accuracy of a combination of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and apparent diffusion coefficient (ADC) values in lesions that manifest with architectural distortion (AD) on mammography. All full-field digital mammography (FFDM) images obtained between August 2010 and January 2013 were reviewed retrospectively, and 57 lesions showing AD were included in the study. Two independent radiologists reviewed all mammograms and MRI data and recorded lesion characteristics according to the BI-RADS lexicon. The gold standard was histopathologic results from biopsies or surgical excisions and results of the two-year follow-up. Receiver operating characteristic curve analysis was carried out to define the most effective threshold ADC value to differentiate malignant from benign breast lesions. We investigated the sensitivity and specificity of FFDM, DCE-MRI, FFDM+DCE-MRI, and DCE-MRI+ADC. Of the 57 lesions analyzed, 28 were malignant and 29 were benign. The most effective threshold for the normalized ADC (nADC) was 0.61 with 93.1% sensitivity and 75.0% specificity. The sensitivity and specificity of DCE-MRI combined with nADC was 92.9% and 79.3%, respectively. DCE-MRI combine...Continue Reading

Citations

Nov 2, 2018·AJR. American Journal of Roentgenology·Hannah PerryTejas S Mehta
Feb 1, 2020·European Radiology·Yoav AmitaiVivianne Freitas
Nov 8, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Kimeya F GhaderiTejas S Mehta

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