MRI measurement of liver regeneration in mice following partial hepatectomy

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Joel R GarbowM W Flye

Abstract

Improvements in noninvasive imaging modalities are crucial for preoperative in vivo assessments of liver condition and potential for regeneration after liver resection for removal of liver tumors. To that end, an MRI study of liver regeneration in mice following partial hepatectomy is described and validated. Hepatic volumes were accurately measured from contrast-enhanced, gradient-echo images of the liver. Regeneration curves were constructed for a series of mice (N = 6) from a longitudinal MR study, with images collected 1, 2, 3, 4, 5, and 9 days following surgery. We validated the MR method by correlating serial MR-measured volumes with liver wet weight. The success of this method will enable future studies to better elucidate the factors that affect regeneration, and help to optimize the timing and dosing of chemotherapeutics to minimize their deleterious effects on liver regeneration.

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Citations

Dec 18, 2013·The Journal of Surgical Research·Emmanuel MelloulMickael Lesurtel
Feb 14, 2007·NMR in Biomedicine·Yusuke InoueKuni Ohtomo
Jan 11, 2021·European Journal of Medical Research·Can KamaliFelix Krenzien

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