MRI measurement of the BOLD-specific flow-volume relationship during hypercapnia and hypocapnia in humans

NeuroImage
J Jean Chen, G Bruce Pike

Abstract

It is widely assumed in fMRI that the relationship between cerebral blood flow (CBF) and volume (CBV) changes observed during end-tidal CO(2) (PETCO(2)) perturbations is equivalent to that elicited by neuronal activation. This assumption has been validated in PET studies insofar as relating total flow to total CBV changes, but remains unconfirmed for venous CBV changes, which pertains to the primary vascular compartment modulating the BOLD signal. In this study, we measured CBF and venous CBV changes in healthy subjects in response to graded hypercapnia and hypocapnia, induced using computerized end-tidal CO(2) targeting, with a DeltaPETCO(2) range of between -6 and +9 mm Hg. Hypercapnia was found to elicit robust increases in CBF and venous CBV, while hypocapnia produced decreases in both. We used steady-state flow and volume changes to estimate the power-law relationship for cortical and subcortical brain regions, and did not observe significant difference between the two. The combined fit resulted in a power coefficient of 0.18+/-0.02, substantially lower than Grubb's coefficient of 0.38, but comparable to previous observations during neuronal activation. These results confirm that the BOLD-specific flow-volume relationship ...Continue Reading

Citations

Apr 1, 2013·Psychometrika·Thomas T LiuGregory G Brown
Oct 19, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·David A Boas, Maria Angela Franceschini
May 11, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 3, 2014·NeuroImage·Matthew J P Barrett, Vinod Suresh
Jul 17, 2015·Human Brain Mapping·J B De VisE T Petersen
Aug 9, 2015·NeuroImage·Martin HavlicekKamil Uludag
Apr 11, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yuji ShenChristian Schwarzbauer
Oct 24, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Pelin Aksit CirisR Todd Constable
Mar 3, 2015·Journal of Magnetic Resonance Imaging : JMRI·Clarisse I MarkJ Jean Chen
Sep 14, 2012·NeuroImage·Ian D DriverPenny A Gowland
Mar 1, 2012·NeuroImage·Richard D Hoge
Apr 11, 2015·Medical Hypotheses·F B TancrediR D Hoge
Jul 11, 2012·NeuroImage·Tomoki ArichiA David Edwards
Jul 2, 2016·NeuroImage·Maria GuidiHarald E Möller
Nov 4, 2016·Journal of Magnetic Resonance Imaging : JMRI·Felipe Rodrigues BarretoCarlos Ernesto Garrido Salmon
Apr 20, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zachary B RodgersFelix W Wehrli
Mar 8, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Seong-Gi Kim, Seiji Ogawa
Dec 15, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Clarisse I Mark, G Bruce Pike
Nov 7, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Binu P ThomasHanzhang Lu
Aug 8, 2017·Human Brain Mapping·James DuffinJoseph Fisher
Feb 28, 2019·NMR in Biomedicine·Glen Robert MorrellVivian Shu-Ching Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.