MRI of blood volume with superparamagnetic iron in choroidal melanoma treated with thermotherapy

Magnetic Resonance Imaging
Matthias H J KrauseLucy H Y Young

Abstract

Functional magnetic resonance imaging (MRI) with a new intravascular contrast agent, monocrystalline iron oxide nanoparticles (MION), was applied to assess the effect of transpupillary thermotherapy in a rabbit model of choroidal melanoma. 3D-spoiled gradient recalled sequences were used for quantitative assessment of blood volume. The MRI-parameters were 5/22/35 degrees (time of repetition (TR)/echo delay (TE)/flip angle (FA)) for T(1)- and 50/61/10 degrees for T(2)-weighted sequences. Images were collected before and at different times after MION injection. In all untreated tissues studied, MION reduced the T(2)-weighted signal intensity within 0.5 h and at 24 h (all p <== 0.012), whereas no significant changes were detected in treated tumors. T(1)-weighted images also revealed differences of MION-related signal changes between treated tumors and other tissues, yet at lower sensitivity and specificity than T(2). The change of T(2)-weighted MRI signal caused by intravascular MION allows early distinction of laser-treated experimental melanomas from untreated tissues. Further study is necessary to determine whether MRI can localize areas of tumor regrowth within tumors treated incompletely.

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Citations

Jan 17, 2014·Journal of Chemical Biology·Ahmad Abolpour HomaeiRoberto Stevanato
Jul 28, 2006·Colloids and Surfaces. B, Biointerfaces·Shupeng LiuYuhong Xu
Mar 12, 2005·Magnetic Resonance Imaging Clinics of North America·Maureen N Hood, Vincent B Ho
Nov 8, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karen C Briley-SaeboZahi A Fayad
Feb 1, 2007·Journal of the American Chemical Society·Chia-Hao SuChen-Sheng Yeh

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