MRI of Extramural Venous Invasion in Locally Advanced Rectal Cancer: Relationship to Tumor Recurrence and Overall Survival

Radiology
Xiao-Yan ZhangYing-Shi Sun

Abstract

Purpose To study the relationship between MRI-defined extramural venous invasion (EMVI) prior to treatment and prognosis in patients with locally advanced rectal cancer treated with neoadjuvant chemotherapy-radiation therapy followed by surgery. Materials and Methods This retrospective study included 517 patients with locally advanced rectal cancer evaluated from August 2008 to December 2014. Baseline and posttherapy MRI and follow-up data were retrieved for all patients. After training by using 328 cases with pathologic evaluation of EMVI after therapy, radiologists evaluated baseline MRI for EMVI status in addition to tumor size and characteristics, nodal status, and invasion of the mesorectal fascia. Reader reproducibility was determined by using κ coefficient. Kaplan-Meier curves and adjusted Cox models were used to determine the relationship of baseline MRI parameters to overall survival, metastasis-free survival, and local relapse-free survival. Results Among 517 patients, 335 (64.8%) were men; the mean age was 55.6 years ± 11.5 (standard deviation). At baseline, radiologists identified 259 of 517 (50%) patients with EMVI by using MRI. In adjusted analysis, EMVI and mesorectal fascial invasion at baseline MRI were predict...Continue Reading

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Citations

Oct 10, 2019·The British Journal of Radiology·Shuai WangYing-Shi Sun
Apr 7, 2019·Abdominal Radiology·Dhakshinamoorthy GaneshanCourtney C Moreno
Dec 17, 2020·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Ulrike Irmgard AttenbergerRalf Dieter Hofheinz
Sep 26, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yanfen CuiXiaotang Yang
Jan 24, 2021·Current Problems in Diagnostic Radiology·Sonsoles Junquera-OlayRoberto Garcia-Figueiras
Jun 14, 2021·International Journal of Radiation Oncology, Biology, Physics·Jessica Juliana TanGina Brown
May 6, 2021·AJR. American Journal of Roentgenology·Harmeet KaurGeorge Chang

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