PMID: 8957798Nov 1, 1996Paper

MRI of microadenomas in patients with hyperprolactinaemia

Neuroradiology
T RandS Trattnig

Abstract

MRI is a sensitive tool for the investigation of pituitary microadenomas but cannot be used as a screening investigation. To establish a strategy for the use of MRI in patients with hyperprolactinaemia we investigated 74 women with serum prolactin levels above 52 ng/ml for the presence of microadenomas. We examined 55 premenopausal and 19 postmenopausal women, using a 1.5 T unit. We used T1-weighted spin-echo sequences, with coronal and sagittal images before and after intravenous gadolinium. We found microadenomas in 38 patients (51.3%), macroadenomas in 6 (8.1%) and an infundibular glioma in 1;29 patients had a normal pituitary gland (39.2%). The size of the adenomas was related to the prolactin level, and the mean level in patients with MRI evidence of adenomas was higher than in patients without microadenomas (155.72 +/- 131.01 ng/ml versus 110.14 +/- 80.86 ng/ml). The probability of the presence of an adenoma increased with rising serum prolactin levels. We suggest MRI in patients with prolactin levels more than 100 ng/ml. In patients on oestrogen therapy MRI should be performed with only slightly elevated prolactin levels. Evidence of a microadenoma should be considered in planning further therapy, especially concerning t...Continue Reading

Citations

Dec 22, 2011·Endocrine·Serhat IsikSerdar Guler
Jan 26, 2002·European Journal of Radiology·Thomas RandS Trattnig
Aug 1, 1998·Seminars in Ultrasound, CT, and MR·C E Swallow, A G Osborn
Nov 18, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Pier Giorgio Crosignani

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