MRI of rod cell compartment-specific function in disease and treatment in vivo.

Progress in Retinal and Eye Research
Bruce A BerkowitzRobin Roberts

Abstract

Rod cell oxidative stress is a major pathogenic factor in retinal disease, such as diabetic retinopathy (DR) and retinitis pigmentosa (RP). Personalized, non-destructive, and targeted treatment for these diseases remains elusive since current imaging methods cannot analytically measure treatment efficacy against rod cell compartment-specific oxidative stress in vivo. Over the last decade, novel MRI-based approaches that address this technology gap have been developed. This review summarizes progress in the development of MRI since 2006 that enables earlier evaluation of the impact of disease on rod cell compartment-specific function and the efficacy of anti-oxidant treatment than is currently possible with other methods. Most of the new assays of rod cell compartment-specific function are based on endogenous contrast mechanisms, and this is expected to facilitate their translation into patients with DR and RP, and other oxidative stress-based retinal diseases.

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Citations

Jul 20, 2018·Investigative Ophthalmology & Visual Science·Bruce A BerkowitzRobin Roberts
Dec 15, 2018·Investigative Ophthalmology & Visual Science·Bruce A BerkowitzRobin Roberts
Apr 18, 2019·Investigative Ophthalmology & Visual Science·Bruce A BerkowitzHaohua Qian
Jun 28, 2019·Investigative Ophthalmology & Visual Science·Claudia LunghiMaria Concetta Morrone
Jun 9, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bruce A BerkowitzRobin Roberts
Nov 15, 2020·Progress in Retinal and Eye Research·Deoye Tonade, Timothy S Kern
Nov 7, 2020·Investigative Ophthalmology & Visual Science·Bruce A BerkowitzRobin Roberts
May 25, 2021·Experimental Biology and Medicine·Bruce A Berkowitz, Haohua Qian

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