MRI phenotype of breast cancer: Kinetic assessment for molecular subtypes

Journal of Magnetic Resonance Imaging : JMRI
Eric Blaschke, Hiroyuki Abe

Abstract

To evaluate the dynamic contrast-enhanced magnetic resonance imaging (MRI) kinetic characteristics of newly diagnosed breast cancer molecular subtypes. Breast MRI examinations of 112 patients with newly diagnosed breast cancer were reviewed. Cases of newly diagnosed invasive ductal carcinoma were sorted by molecular subtype (28 TN, 11 HER2 +, 73 Lum A/B) and MRI field strength, with lesion segmentation and kinetic analyses performed on a dedicated workstation. For kinetic assessment, 50% and 100% thresholds were employed for display of medium and rapid uptake. Kinetic profiles in terms of percent volume for six kinetic types (medium-persistent, medium-plateau, medium-washout, fast-persistent, fast-plateau, fast-washout) relative to the whole volume of the lesion were obtained. Statistical analysis of the kinetic profiles was performed using Welch's t-test. Percent volume of HER2-positive lesions with >100% uptake at early phase on 3T strength MRI exams was significantly greater compared with luminal A/B (93.8 ± 0.92 vs. 77.3 ± 7.2; P < 0.01) and triple negative (93.8 ± 0.92 vs. 81.3 ± 8.2; P < 0.05) subtypes. The >50% early phase uptake for HER2+ lesions was also higher than Lum A/B (99.1 ± 0.73 vs. 93.6 ± 3.05; P < 0.01) at 3T...Continue Reading

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Citations

Dec 15, 2015·Journal of Magnetic Resonance Imaging : JMRI·Lars J Grimm
Sep 17, 2015·The British Journal of Radiology·Almir G V BitencourtElvira F Marques
Feb 11, 2018·Journal of Cancer Research and Clinical Oncology·Ashirbani SahaMaciej A Mazurowski
Jan 24, 2019·Journal of Magnetic Resonance Imaging : JMRI·Maciej A MazurowskiP Kelly Marcom
Aug 30, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Maria Adele MarinoMaxine Jochelson
May 8, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Sachiko YuenKazuhiko Yamagami
Jun 6, 2018·La Radiologia medica·Marco MacchiniGian Marco Giuseppetti
Jul 24, 2018·British Journal of Cancer·Ashirbani SahaMaciej A Mazurowski
Jun 5, 2018·International Journal of Breast Cancer·Eleanor E R Harris
Nov 3, 2017·Journal of Magnetic Resonance Imaging : JMRI·Katja PinkerElizabeth A Morris
Jul 13, 2020·The Breast Journal·Jessica H PorembkaHuong T Le-Petross
Jun 20, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hyunjin ParkKo Woon Park
May 3, 2019·Computers in Biology and Medicine·Zhe ZhuMaciej A Mazurowski
Dec 11, 2019·Academic Radiology·Lars J Grimm, Maciej A Mazurowski

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