MRI supervised and unsupervised classification of Parkinson's disease and multiple system atrophy

Movement Disorders : Official Journal of the Movement Disorder Society
Patrice PéranOlivier Rascol

Abstract

Multimodal MRI approach is based on a combination of MRI parameters sensitive to different tissue characteristics (eg, volume atrophy, iron deposition, and microstructural damage). The main objective of the present study was to use a multimodal MRI approach to identify brain differences that could discriminate between matched groups of patients with multiple system atrophy, Parkinson's disease, and healthy controls. We assessed the 2 different MSA variants, namely, MSA-P, with predominant parkinsonism, and MSA-C, with more prominent cerebellar symptoms. Twenty-six PD patients, 29 MSA patients (16 MSA-P, 13 MSA-C), and 26 controls underwent 3-T MRI comprising T2*-weighted, T1-weighted, and diffusion tensor imaging scans. Using whole-brain voxel-based MRI, we combined gray-matter density, T2* relaxation rates, and diffusion tensor imaging scalars to compare and discriminate PD, MSA-P, MSA-C, and healthy controls. Our main results showed that this approach reveals multiparametric modifications within the cerebellum and putamen in both MSA-C and MSA-P patients, compared with PD patients. Furthermore, our findings revealed that specific single multimodal MRI markers were sufficient to discriminate MSA-P and MSA-C patients from PD pa...Continue Reading

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Citations

Mar 29, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Florian KrismerChristoph Scherfler
Sep 26, 2019·The Journal of International Medical Research·Jing GuoYong Luo
Feb 13, 2020·Current Opinion in Neurology·Germain Arribarat, Patrice Péran
Sep 17, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Florian KrismerChristoph Scherfler
Apr 2, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Chenjie Xia, Ronald B Postuma
Aug 28, 2020·Frontiers in Neurology·Germain ArribaratPatrice Péran
Aug 9, 2020·Frontiers in Neurology·Lydia ChougarStéphane Lehéricy
Jul 25, 2019·Frontiers in Neuroanatomy·Amaury De BarrosPatrice Péran
May 26, 2018·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Jeremy K Cutsforth-Gregory
Aug 28, 2019·Journal of Parkinson's Disease·Morinobu SekiChristoph Scherfler
Nov 7, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Wassilios G MeissnerOlivier Rascol
Nov 3, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Lydia ChougarStéphane Lehéricy
Jan 4, 2021·Brain Structure & Function·Amaury De BarrosPatrice Péran
Oct 13, 2020·Movement Disorders Clinical Practice·Maria Teresa PellecchiaUNKNOWN Members of the Movement Disorder Society Multiple System Atrophy Study Group
Nov 13, 2020·Frontiers in Neurology·Usman SaeedMario Masellis
Apr 9, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Xuehan HuXiaoli Lan
Apr 25, 2021·Lancet Neurology·Eduardo TolosaWerner Poewe
Jul 3, 2021·Brain Sciences·Paola FeracoRoberto Monastero
Jul 14, 2021·Expert Review of Neurotherapeutics·Luca MarsiliCarlo Colosimo
May 20, 2021·Current Opinion in Neurology·Lydia ChougarStéphane Lehéricy
Oct 6, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Aurelija JucaiteLars Farde

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