MRI surveillance for women with dense breasts and a previous breast cancer and/or high risk lesion

The Breast : Official Journal of the European Society of Mastology
Michelle NadlerB Curpen

Abstract

The role of surveillance breast MRI for women with mammographically dense breasts, a personal history of breast cancer (BC), atypical hyperplasia (AH), or lobular carcinoma in situ (LCIS) is unclear. We estimated the performance of annual surveillance MRI in women with a combination of these risk factors. We performed a retrospective review of the clinical, radiological, and pathological parameters of women who received annual concurrent surveillance breast MRI and mammography between 04/2013 and 12/2015 and fulfilled all of the following criteria: 1) age <70; 2) prior diagnosis of AH, LCIS or BC; 3) heterogeneously or extremely dense breast(s); and 4) did not qualify for our provincial breast MRI high risk screening program. This study included 198 patients (266 MRI exams). MRI detected 15 cancers: 11 invasive stage I and 4 in-situ. All but 1 were mammographically occult and there were no interval cancers. The cancer detection rate (CDR) and false positive (FP) rate were 6.1% and 21% for round one and 4.7% and 12.5% for round two, respectively. Not being on anti-estrogen therapy and having a 1st degree relative with BC significantly increased the likelihood of tumor detection. The CDR and FP rate of surveillance MRI in this st...Continue Reading

Citations

Apr 12, 2019·The Breast Journal·Sona A Chikarmane, Catherine S Giess
Sep 12, 2020·The American Journal of the Medical Sciences·Anahid M PahlawanianAgustin A Garcia
Jul 19, 2019·Breast Care·Giovanna Negrão de FigueiredoEva Maria Fallenberg

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