PMID: 9437774Jan 23, 1998Paper

MRI T2 relaxation times of brain regions in schizophrenic patients and control subjects

Psychiatry Research
T SupprianT Becker

Abstract

In this MRI investigation T2 relaxation times were studied in schizophrenic patients compared to normal control subjects. Approximate T2 relaxation times were calculated using signal intensity at two echo times in several brain regions of 25 male schizophrenic patients and 25 age-matched, normal male control subjects. The schizophrenic patients showed significantly longer T2 relaxation times as compared to normal control subjects in the left anterior column of the fornix. This is a small structure, prone to partial volume effects and this may account for these findings. There was a trend towards longer T2 times in the left frontal cortex and shorter T2 times in [corrected] right temporal cortex in schizophrenic patients as compared to control subjects. There were right/left differences in relaxation times within each group. In both patients and control subjects, frontal lobe white matter T2 was longer on the right than on the left side. This finding is probably due to brain asymmetry and unrelated to the presence or absence of psychiatric illness. In schizophrenic patients only the left temporal cortex showed longer T2 times than the right side. This observation could indicate left sided temporal lobe pathology in schizophrenia.

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Citations

May 2, 2000·Magnetic Resonance Imaging·R G SteenR J Ogg
Nov 19, 2003·Psychiatry Research·Vassili A KovalevJohn Suckling
Oct 9, 1999·Psychiatry Research·A PfefferbaumK O Lim
Aug 22, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R W ThatcherA Salazar
Sep 17, 2010·Radiology·Christian LangkammerStefan Ropele
Nov 18, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dost OngürDavid P Olson
Jan 30, 2010·Magnetic Resonance Imaging·Jussi TohkaArthur W Toga
Apr 8, 2014·Cerebral Cortex·O PhillipsM Di Paola
May 12, 2015·Magnetic Resonance Imaging·Prerna KhuranaAngshul Majumdar
May 12, 2009·NeuroImage·Berengere Aubert-BrocheD Louis Collins
Aug 9, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ivan I Kirov, Assaf Tal

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