MRI techniques and cognitive impairment in the early phase of relapsing-remitting multiple sclerosis

Neuroradiology
R ZivadinovM Zorzon

Abstract

Correlation studies between various conventional and non-conventional MRI parameters and cognitive impairment in the early stages of multiple sclerosis (MS) are lacking, although it is known that a number of patients with early MS have mild cognitive impairment. Our aim was to explore whether this cognitive impairment is dependent on the extent and severity of the burden of disease, diffuse microscopic brain damage or both. We studied 63 patients with clinically definite relapsing-remitting (RR) MS, duration of disease 1-10 years and Expanded disability status scale scores < or = 5.0. Mean age was 35.4 years, mean duration of disease 5.8 years and median EDSS score 1.5. Neuropsychological performance, psychological function, neurological impairment and disability were assessed. The patients also underwent MRI, including magnetisation-transfer (MT) studies. We quantified the lesion load on T2- and T1-weighted images, the magnetisation transfer ratio (MTR) of normal-appearing brain tissue (NABT) and the brain parenchymal fraction (BPF). No significant difference was found between lesion loads in patients with and without cognitive impairment. In 15 patients (23.8%) with overall cognitive impairment, median BPF and average NABT MT...Continue Reading

Citations

Jul 28, 2009·Journal of Neurology·Milena StosicRobert Zivadinov
May 9, 2003·Journal of the Neurological Sciences·Robert ZivadinovGiuseppe Cazzato
Sep 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M ZorzonG Cazzato
Oct 28, 2008·Brain : a Journal of Neurology·R A DineenD P Auer
Jul 20, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F BagnatoE Millefiorini
Aug 30, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M P SánchezM A Hernández
Mar 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·M S A DeloireB Brochet
May 14, 2009·Multiple Sclerosis : Clinical and Laboratory Research·L K FisnikuD H Miller
May 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Rohit BakshiJerry S Wolinsky
Jun 5, 2002·Current Opinion in Neurology·Peter Rieckmann, Mathias Mäurer
Jun 5, 2002·Current Opinion in Neurology·Frederik Barkhof
Mar 18, 2010·International Review of Psychiatry·Lambros MessinisPanagiotis Papathanasopoulos
Mar 13, 2010·International Review of Psychiatry·Epameinondas LyrosPanagiotis Papathanasopoulos
Apr 21, 2006·Expert Review of Neurotherapeutics·Francesca BagnatoVasiliki N Ikonomidou
Mar 15, 2006·Expert Review of Neurotherapeutics·Ayda Tekok-KilicRobert Zivadinov
Sep 18, 2007·Expert Review of Neurotherapeutics·Adrienne R Boissy, Jeffrey A Cohen
Jun 17, 2011·Clinical Linguistics & Phonetics·Michel Paradis
Feb 12, 2014·Magnetic Resonance Imaging·Katherine A KoenigMicheal D Phillips
Nov 30, 2013·Neurologic Clinics·John A Bertelson, Bela Ajtai
Feb 24, 2016·International Journal of Biomedical Imaging·Roey MechrezHayit Greenspan
Jan 20, 2016·Neurodegenerative Disease Management·Robert W MotlRalph H B Benedict
Dec 11, 2008·Neuroimaging Clinics of North America·Antonio GiorgioNicola De Stefano
Feb 11, 2015·Lancet Neurology·Maria A RoccaUNKNOWN MAGNIMS Study Group
Mar 5, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Christopher W TjoaRobert Zivadinov
Oct 13, 2006·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jitendra SharmaRohit Bakshi
Apr 12, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Nicola De StefanoStephen M Smith
Sep 20, 2012·Acta Neurologica Scandinavica·G BergendalO Almkvist
Jul 16, 2010·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Giuseppe BomboiFrancesca Bagnato
Sep 1, 2004·Journal of the Neurological Sciences·Robert ZivadinovMarino Zorzon
Jun 30, 2004·Journal of Neuroimmunology·Nicola FiottiMarino Zorzon
Apr 22, 2006·Journal of the Neurological Sciences·Ralph H B Benedict, Robert Zivadinov
Apr 22, 2006·Journal of the Neurological Sciences·Marco RovarisMassimo Filippi
Apr 22, 2006·Journal of the Neurological Sciences·Mojtaba Zarei
Apr 25, 2006·Journal of the Neurological Sciences·Jean-Philippe RanjevaPatrick J Cozzone
Apr 26, 2006·Journal of the Neurological Sciences·A Achiron, Y Barak
Mar 31, 2015·PloS One·Francesco PattiGioacchino Tedeschi
Sep 2, 2016·Acta Neurologica Scandinavica·F Paul

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.