MRI UTE-T2* shows high incidence of cartilage subsurface matrix changes 2 years after ACL reconstruction

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
A A WilliamsConstance R Chu

Abstract

Alteration of deep cartilage matrix has been observed following anterior cruciate ligament (ACL) injury, evidenced by elevated MRI UTE-T2* values measured in small, 2-D cartilage regions of interest. This Level I diagnostic study seeks to more thoroughly evaluate deep cartilage matrix changes to medial tibiofemoral UTE-T2* maps 2 years after ACL reconstruction and examine the relative utilities of 3-D compared to 2-D assessments of cartilage UTE-T2* maps. Thirty-eight ACL-reconstructed and 20 uninjured subjects underwent MRI UTE-T2* mapping. "Small" single mid-sagittal 2-D and larger 3-D "tread mark" regions of interest were manually segmented and found to be correlated in medial cartilage (r > 0.58, p < 0.005). 3-D analyses of UTE-T2* maps showed differences to medial tibial cartilage between ACL-reconstructed and uninjured subjects (p = 0.007) that were not detected by smaller 2-D regions (p > 0.46). Quantitative comparisons show 14/38 (37%) ACL-reconstructed subjects have values >2 standard deviations higher than uninjured controls. Among a subset of ACL-reconstructed subjects with no morphologic MRI evidence of medial tibiofemoral cartilage or meniscal pathology (n = 12), elevated UTE-T2* values in "small" 2-D femoral (p = ...Continue Reading

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Jul 7, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ashley WilliamsConstance R Chu
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Citations

Jun 15, 2019·Haemophilia : the Official Journal of the World Federation of Hemophilia·Annette von DrygalskiEric Y Chang
Mar 5, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Abdul Wahed KajabiMiika T Nieminen
Aug 23, 2019·Journal of Athletic Training·Constance R Chu
May 20, 2020·Orthopaedic Journal of Sports Medicine·Cameron KiaRobert A Arciero
Jan 9, 2021·Osteoarthritis and Cartilage·F EcksteinA G Culvenor
Dec 27, 2019·Osteoarthritis and Cartilage·R KijowskiA Guermazi
Apr 1, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Constance R ChuThomas P Andriacchi
Sep 8, 2021·Radiology·Majid ChalianUNKNOWN SNA QIBA MSK Biomarker Committee Members
Jan 6, 2022·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yanjun ChenYa-Jun Ma

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