MRI virtual biopsies: analysis of an explanted endovascular device and perspectives for the future

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
Robert GuidoinR Guzman

Abstract

Information that can be obtained by magnetic resonance imaging (MRI) of explanted endovascular devices must be validated as this method is non-destructive. Histology of such a device together with its encroached tissues can be elegantly performed after polymethymethacrylate (PMMA) embedding, but this approach requires destruction of the specimen. The issue is therefore to determine if the MRI is sufficient to fully validate an explanted device based upon the characterization of an explanted specimen. An AneuRx device deployed percutaneously 25 months earlier in a 75-year-old patient was removed en bloc at autopsy together with the surrounding aneurysmal sac and segments of the upstream and downstream arteries. Macroscopic pictures were taken and a slice of the cross-section was processed for histology after polymethylmethacrylate (PMMA) embedding. For the magnetic resonance imaging investigation, the device was inserted in a Biospec 4.7 T MRI system with a 20 mm diameter birdcage resonator used for both emission and reception. A Spin-Echo (SE) was used to acquire both T1 proton density (PD) and T2 weighted images. A gradient-echo (GE) sampling of a free induction decay (GESFID) was used to generate multiple GE images using a si...Continue Reading

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Citations

Apr 25, 2007·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Amidou S TraoréAndré-Pierre Legrand
Jul 1, 2006·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·R GuidoinR Guzman

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