MRI visible drug eluting magnetic microspheres for transcatheter intra-arterial delivery to liver tumors

Theranostics
Dong-Hyun KimAndrew C Larson

Abstract

Magnetic resonance imaging (MRI)-visible amonafide-eluting alginate microspheres were developed for targeted arterial-infusion chemotherapy. These alginate microspheres were synthesized using a highly efficient microfluidic gelation process. The microspheres included magnetic clusters formed by USPIO nanoparticles to permit MRI and a sustained drug-release profile. The biocompatibility, MR imaging properties and amonafide release kinetics of these microspheres were investigated during in vitro studies. A xenograft rodent model was used to demonstrate the feasibility to deliver these microspheres to liver tumors using hepatic transcatheter intra-arterial infusions and potential to visualize the intra-hepatic delivery of these microspheres to both liver tumor and normal tissues with MRI immediately after infusion. This approach offer the potential for catheter-directed drug delivery to liver tumors for reduced systemic toxicity and superior therapeutic outcomes.

Citations

Mar 1, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Azadeh PoursaidHamidreza Ghandehari
Nov 11, 2016·Biomedical Microdevices·Sravani KondapavulurSteven W Hetts
Nov 17, 2017·Biomaterials Science·Wooram ParkDong-Hyun Kim
Jun 7, 2019·Advanced Materials·Jingjie HuRahmi Oklu
Oct 27, 2018·Journal of Imaging·Dong-Hyun Kim
May 18, 2021·Bioactive Materials·Jianling WangKelong Ai
Aug 19, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Guorong JiaKai Chen
Sep 1, 2021·Journal of Vascular and Interventional Radiology : JVIR·Ivan P DimovGilles Soulez

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Methods Mentioned

BETA
acetylation
xenograft
chips
Scanning
FCS
sedation
confocal microscopy
FACS

Software Mentioned

HistoQuest
Image J
Origin
CellQuest
FCS Express

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