mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases

Molecular Therapy : the Journal of the American Society of Gene Therapy
Giulietta MaruggiDong Yu

Abstract

In the last two decades, there has been growing interest in mRNA-based technology for the development of prophylactic vaccines against infectious diseases. Technological advancements in RNA biology, chemistry, stability, and delivery systems have accelerated the development of fully synthetic mRNA vaccines. Potent, long-lasting, and safe immune responses observed in animal models, as well as encouraging data from early human clinical trials, make mRNA-based vaccination an attractive alternative to conventional vaccine approaches. Thanks to these data, together with the potential for generic, low-cost manufacturing processes and the completely synthetic nature, the prospects for mRNA vaccines are very promising. In addition, mRNA vaccines have the potential to streamline vaccine discovery and development, and facilitate a rapid response to emerging infectious diseases. In this review, we overview the unique attributes of mRNA vaccine approaches, review the data of mRNA vaccines against infectious diseases, discuss the current challenges, and highlight perspectives about the future of this promising technology.

Citations

Sep 25, 2019·Vaccines·Leroy VersteegJeroen Pollet
Feb 26, 2020·Nanomaterials·Itziar Gómez-AguadoAna Del Pozo-Rodríguez
Feb 6, 2020·Pharmaceutics·Abishek WadhwaAneesh Thakur
May 8, 2020·International Journal of Molecular Medicine·Daniela CalinaAristidis Tsatsakis
Jul 11, 2020·Biomimetics·Ana Maria Carmona-Ribeiro, Yunys Pérez-Betancourt
Feb 13, 2020·NPJ Vaccines·Nicholas A C JacksonFrank DeRosa
Jul 28, 2019·Journal of Translational Medicine·Patrick Tjok JoeJoeri L Aerts
Jul 31, 2020·Virology Journal·Yicheng YangWei Zhao
Oct 6, 2020·Journal of the Indian Institute of Science·Shahid Jameel
Jun 12, 2020·Virologica Sinica·Changhua YiJunwei Li
Oct 6, 2020·Frontiers in Immunology·Maria TrovatoPiergiuseppe De Berardinis
May 14, 2020·Acta Pharmacologica Sinica·Wei-Min YinMin Luo
Sep 13, 2020·International Journal of Molecular Sciences·Shuqin XuLu Zhang
Sep 8, 2020·Angewandte Chemie·Christoph O FranckLjiljana Fruk
Aug 17, 2020·Cell·Na-Na ZhangCheng-Feng Qin
Jan 13, 2021·Proceedings of the National Academy of Sciences of the United States of America·Rino RappuoliEmmanuel Hanon
Jan 23, 2021·Vaccines·Michael D BuschmannDrew Weissman
Feb 6, 2021·Pharmaceutics·Basmah N AldosariAlanood S Almurshedi
Jan 23, 2021·Advanced Drug Delivery Reviews·Saborni ChakrabortyTaia T Wang
Oct 24, 2020·Gene Therapy·Kristie BloomPatrick Arbuthnot
Jan 9, 2021·Frontiers in Immunology·Jonas B Sandbrink, Robin J Shattock
Feb 3, 2021·Vaccines·Anna K BlakneyAndrew J Geall
Dec 20, 2020·Vaccines·Andrea ChiricozziGiampiero Girolomoni
Jan 6, 2021·Pharmaceutics·Iman M AlfagihMariyam M Alfagih
Jan 13, 2021·Trends in Biotechnology·Richard I KitneyJim Philp
Feb 3, 2021·American Journal of Obstetrics and Gynecology·Irene A StaffordBaha M Sibai
Mar 5, 2021·International Journal of Dermatology·Diego Fernandez-NietoSonia Bea-Ardebol
Feb 26, 2021·Travel Medicine and Infectious Disease·Patricia SchlagenhaufKarin Leder
Feb 4, 2021·NPJ Vaccines·Nicholas A C JacksonFrank DeRosa
Jun 15, 2020·Life Sciences·Satish Chandra PandeyMukesh Samant
Jan 30, 2021·Advances in Biomarker Sciences and Technology·Luoping Zhang, Helen Guo
Jul 4, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gustavo LouYvonne Perrie
Aug 30, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rui ZhangLi Yang
Mar 28, 2021·Vaccine·Sara Sousa RosaMarco P C Marques
Mar 28, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wei ZhangKyle K L Phua
Dec 10, 2020·Cytokine & Growth Factor Reviews·Moiz Bakhiet, Sebastien Taurin
Apr 1, 2021·Curēus·Nurith HillerNatalia Simanovsky
Nov 9, 2019·Trends in Molecular Medicine·Sergio Linares-FernándezBernard Verrier
Sep 10, 2020·Asian Journal of Pharmaceutical Sciences·Lanxiang HuangFubing Wang
Apr 20, 2021·Frontiers in Molecular Biosciences·Pobitra BorahDa'san M M Jaradat

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