PMID: 9547169Apr 18, 1998Paper

mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit

Neuroscience Letters
A M SchitoP Mandich

Abstract

The expression of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B/epsilon2 (GRIN2B) in the human adult brain was assayed by in situ hybridisation, by using a specific cRNA probe. The full length GRIN2B cDNA was cloned and sequenced. It showed a 90% nucleotide conservation when compared to the rodent homologue. GRIN2B gene is expressed at high levels in the fronto-parieto-temporal cortex and hippocampus pyramidal cells and, at a lower extent, in the basal ganglia (amygdala and striatum). The cerebellar granule cells does not show any mRNA expression. The non-ubiquitous anatomical distribution of the GRIN2B mRNA in the central nervous system suggests that the gene could be involved in specific functions pertaining to the expressing cell groups.

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Citations

Dec 3, 2013·Journal of Neural Transmission·Virginia AndreoliAntonio Gambardella
Jan 17, 2007·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Dawei Li, Lin He
Jul 17, 2009·Pharmacological Reports : PR·Aleksandra SzczepankiewiczJanusz K Rybakowski
Sep 1, 2015·Journal of Affective Disorders·Fengyuan CheYifeng Du
Jul 11, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Kerstin U LudwigPer Hoffmann
Oct 16, 2014·European Child & Adolescent Psychiatry·Valentina RivaCecilia Marino
Aug 26, 2016·The Journal of Comparative Neurology·Minela HadzicPetra Wahle
Jun 24, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Emilio Di MariaPaola Mandich
Jan 21, 2020·The American Journal on Addictions·Ni FanYufen Ou
Nov 14, 2008·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Aleksandra SzczepankiewiczJoanna Twarowska-Hauser
Sep 11, 2019·International Journal of Molecular Sciences·Zhu ZhangKen Kin-Lam Yung

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