mRNA encoding the catalytic subunit of DNA-dependent protein kinase is widely expressed in Xenopus cells

Gene
P Labhart

Abstract

Here, the sequence of a Xenopus laevis cDNA encoding the 640 carboxy-terminal amino acids of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is reported. The predicted Xenopus protein segment is 65% identical to the human counterpart. Northern blot analysis indicates that Xenopus DNA-PKcs is encoded by an approx. 13000 nt transcript. DNA-PKcs mRNA is widely expressed in adult tissues as well as in oocytes and embryos. It is also shown that outside the conserved kinase domain, Xenopus DNA-PKcs bears significant similarities to hypothetical 420.8 and 433.2 kDa proteins in yeast species.

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Citations

Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yi-Kai ChenTing-Fang Wang
Nov 13, 2004·FEMS Microbiology Reviews·Zuzana DudásováMiroslav Chovanec
Apr 8, 2000·Critical Reviews in Biochemistry and Molecular Biology·R Tuteja, N Tuteja
Feb 18, 2018·The FEBS Journal·Jay H Chung
Mar 19, 1999·Molecular and Cellular Biology·P Labhart

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