mRNA export protein THOC5 as a tool for identification of target genes for cancer therapy

Cancer Letters
D D H TranT Tamura

Abstract

Recent evidence indicates that mRNA export is selective, giving priority to a subset of mRNAs that control diverse biological processes including cell proliferation, differentiation, stress response, and cell survival as well as tumor development. The depletion of a member of the mRNA export complex, the THO complex, impairs the expression of only a subset of genes, but causes dramatic changes in phenotype, such as cell cycle inhibition, abnormal differentiation, and importantly apoptosis of stem cells and cancer cells but not normal epithelial cells, hepatocytes, or fibroblasts. Recent exosome sequence data revealed that over 100 driver gene mutations with a number of signaling pathways are involved in human cancer formation, indicating that multiple signaling pathways will need to be inhibited for cancer therapy. In this review we firstly describe a basic feature and function of the mRNA export complex, THO, secondly, the biological alteration upon depletion of a member of the THO complex in normal and cancer cells, and thirdly, identification of its target genes. Finally we describe our recent data on selection of targeting candidates from THOC5 dependent genes for application in cancer therapy.

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Citations

Jun 9, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alexander F Palazzo, Mathew Truong
Apr 12, 2020·G3 : Genes - Genomes - Genetics·Elliott HaydenShulin Ju
Jul 28, 2018·Nucleic Acids Research·Rashmi MinochaKatja Sträßer
Aug 14, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Rita Loja-ChangoPeter Chedraui
Jan 20, 2021·Chemosphere·Jialu BaoXiaodan Wang

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