mRNA expression of insulin-like growth factor-I (IGF-I) is suppressed and those of IGF-II and IGF-binding protein-1 are constantly expressed in the endometrium during use of an intrauterine levonorgestrel system

Molecular Human Reproduction
E M RutanenT Nyman

Abstract

Insulin-like growth factors (IGF-I and IGF-II) are believed to mediate and modulate steroid hormone actions in the endometrium. In this study we determined the effects of an intrauterine system (IUS), releasing 20 microg levonorgestrel (LNG) daily, on endometrial expression of mRNAs encoding IGFs and insulin-like growth factor binding protein (IGFBP)-1. In Northern blotting, IGF-I mRNA was undetectable in all endometrial specimens from women with an LNG-IUS (n = 11) and in pregnancy decidua, whereas several transcripts of 0.6-7.6 kb were detected in proliferative and secretory phase endometria. In contrast, mRNAs encoding IGF-II and IGFBP-1 were strongly expressed in pregnancy and in all endometrial samples from women with an LNG-IUS, but were undetectable in proliferative or early to mid-secretory phase endometria. Using the more sensitive reverse transcriptase-polymerase chain reaction (RT-PCR) method, IGF-I and IGF-II mRNAs were detectable in all cycling endometria, in early pregnancy decidua and in LNG-exposed endometrium. IGFBP-1 mRNA was constantly expressed in LNG-exposed endometrium, in early pregnancy decidua and in premenstrual endometrium, but was undetectable in all specimens from proliferative or early to mid-secre...Continue Reading

Citations

May 10, 2003·Fertility and Sterility·Vera GrigorievaAnton Mikhailov
Aug 27, 2005·Obstetrical & Gynecological Survey·Jeffrey T Jensen
Aug 11, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M Ibraheim, A Ikomi
Mar 5, 1999·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·E M Rutanen
Feb 9, 2005·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·G BenagianoM Farris
Mar 26, 2002·Climacteric : the Journal of the International Menopause Society·M ReesR Bicknell
Dec 14, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Tiina Backman
Aug 4, 2001·The American Journal of Pathology·E ParrottP Greaves
May 5, 2007·International Journal of Surgical Pathology·Rahul K HejmadiTerence P Rollason
Sep 10, 2020·Expert Review of Clinical Pharmacology·Carlo BastianelliGiuseppe Benagiano

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