mRNA expression of steroidogenic enzymes, steroid hormone receptors and their coregulators in gastric cancer

Oncology Letters
Bartosz Adam FryczPaweł Piotr Jagodziński

Abstract

Epidemiological and experimental findings suggest that the development of gastric cancer (GC) is regulated by steroid hormones. In postmenopausal women and older men, the majority of steroid hormones are produced locally in peripheral tissue through the enzymatic conversion of steroid precursors. Therefore, using reverse transcription-quantitative polymerase chain reaction analysis, the mRNA expression of genes encoding steroidogenic enzymes, including steroid sulfatase (STS), hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase 1 (HSD3B1), 17β-hydroxysteroid dehydrogenase type 7 and aromatase (CYP19A1), was investigated in primary tumoral and adjacent healthy gastric mucosa from 60 patients with GC. Furthermore, the mRNA levels for estrogen receptor α, estrogen receptor β (ESR2) and androgen receptor (AR), along with their coregulators, including proline, glutamate and leucine rich protein 1, CREB binding protein, nuclear receptor coactivator 1 (NCOA1), nuclear receptor corepressor 1 (NCOR1) and nuclear receptor subfamily 2 group F member 1 (NR2F1), were investigated. Additionally, the association between the mRNA expression of these genes and the clinicopathological features of patients with GC was examin...Continue Reading

References

Apr 1, 1972·The Journal of Clinical Investigation·H J RuderM B Lipsett
Apr 16, 1998·Breast Cancer Research and Treatment·E M BernsJ A Foekens
Jan 7, 2000·Biochemical and Biophysical Research Communications·H TaiS Kato
Mar 25, 2000·The Journal of Steroid Biochemistry and Molecular Biology·G S ChetriteJ R Pasqualini
Aug 5, 2000·The Journal of Steroid Biochemistry and Molecular Biology·T UtsumiN Harada
Sep 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·J R Pasqualini, G Chetrite
Jun 20, 2002·Journal of Cancer Research and Clinical Oncology·Satoru MatsuyamaShin-Ichi Hayashi
Dec 20, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Pentti Sipponen, Pelayo Correa
Nov 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·E R Simpson
Nov 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Takashi SuzukiHironobu Sasano
Jan 13, 2004·World Journal of Gastroenterology : WJG·Li-Qun XieHe-Sheng Luo
Jan 31, 2004·Gynecologic Oncology·Sharif M KershahBrian G Rowan
Feb 14, 2004·Journal of Cancer Research and Clinical Oncology·A KomineaA G Papavassiliou
Feb 28, 2004·Life Sciences·Takashi UeyamaYoshihiro Tsuruo
Jan 25, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Zoran CuligAlfred Hobisch
Jul 16, 2005·Cancer Letters·Zhenhuan ZhangHirotaka Iwase
Jan 18, 2006·The Journal of Steroid Biochemistry and Molecular Biology·J R Pasqualini, G S Chetrite
Oct 19, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M WangS-X Qu
Oct 24, 2007·The Journal of Surgical Research·Outi Nylander-KoskiHarri Mustonen
Feb 19, 2008·The American Journal of Psychiatry·Takanori HashimotoDavid A Lewis
Jul 3, 2008·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Masao IzawaMasahide Ikeguchi
Aug 30, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Evangelos Chandanos, Jesper Lagergren
Oct 1, 2008·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Evangelos ChandanosJesper Lagergren
Oct 11, 2008·Endocrine-related Cancer·Stephen A BoorjianDonald J Tindall
Dec 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shu WangJianming Xu
Jan 23, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Masayo SuzukiNobuhiro Harada
Jun 16, 2009·Molecular and Cellular Endocrinology·A M HoganD C Winter
Feb 12, 2010·Nature Reviews. Cancer·Gail P RisbridgerWayne D Tilley
Aug 17, 2010·Advanced Drug Delivery Reviews·Erin K Shanle, Wei Xu
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Oct 27, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·M Constanza CamargoCharles S Rabkin
Nov 11, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Makoto OzawaYasuyoshi Watanabe
Mar 17, 2012·Journal of Surgical Oncology·Woo-Sang RyuChong-Suk Kim

❮ Previous
Next ❯

Citations

Sep 27, 2019·Journal of Cellular and Molecular Medicine·Juan-Cheng YangWen-Lung Ma
Mar 31, 2021·Expert Opinion on Therapeutic Patents·Hanan S AnbarMohammed I El-Gamal

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis

Software Mentioned

STATISTICA
OLIGO Primer Analysis

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Bartosz Adam FryczPaweł Piotr Jagodziński
European Journal of Endocrinology
Nathalie NicolaiewOlivier Cussenot
Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Tina SmucTea Lanisnik Rizner
© 2022 Meta ULC. All rights reserved