mRNA expression profile in peripheral blood mononuclear cells based on ADRB1 Ser49Gly and Arg389Gly polymorphisms in essential hypertension - a case-control pilot investigation in South Indian population

Clinical Chemistry and Laboratory Medicine : CCLM
Varsha VarakanthamDinesh Kumar Bharatraj

Abstract

β1-Adrenoreceptor (ADRB1) genetic polymorphisms are widely studied for susceptibility to many cardiovascular diseases such as essential hypertension. However, the mRNA expression of ADRB1 is rarely studied. A case-control pilot study with 292 hypertensives and 324 controls was designed to evaluate the role of the Ser49Gly and Arg389Gly, which are commonly studied single nucleotide polymorphisms (SNP), in the mRNA levels of ADRB1, in conjunction with its genetic predisposition to essential hypertension. Differential expression of ADRB1 mRNA was seen between hypertensives and controls (p<0.01) based on genetic variants of Ser49Gly. Among hypertensive subjects, Ser49Ser and Gly49Gly were highly expressed in comparison to Ser49Gly (p<0.05 and p<0.01, respectively), whereas genetic variants of Arg389Gly did not demonstrate any such variations. We found no association between the ADRB1 SNPs viz., Ser49Gly and Arg389Gly and essential hypertension. The increased mRNA levels of Gly49Gly may indicate a plausible role in the interindividual variations in drug response. Further, ADRB1 polymorphisms did not contribute to the genetic risk of essential hypertension. Studies with larger sample size are warranted to confirm these observations i...Continue Reading

References

Apr 28, 1995·European Journal of Pharmacology·D E BerkowitzD A Schwinn
Mar 1, 1993·Current Opinion in Nephrology and Hypertension·J M Wyss
Apr 29, 1996·European Journal of Pharmacology·J C MakP J Barnes
Apr 23, 1999·The Journal of Biological Chemistry·D A MasonS B Liggett
Aug 12, 1999·European Journal of Pharmacology·C GiesslerO E Brodde
Aug 17, 1999·Biochemical Pharmacology·N MatsudaM Kanno
Oct 5, 2001·Trends in Genetics : TIG·S V Naga PrasadH A Rockman
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M IemitsuI Yamaguchi
Jan 16, 2002·Journal of Cardiovascular Pharmacology·Deborah A RathzStephen B Liggett
Apr 2, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Keisuke ShiojiNaoharu Iwaii
Dec 8, 2004·Analytical Biochemistry·Tomas MasekMartin Pospisek
Jan 24, 2006·Life Sciences·Jaromír MyslivecekRichard Kvetnanský
Mar 1, 2006·BMC Bioinformatics·Joshua S YuanC Neal Stewart
Sep 4, 2009·Current Pharmacogenomics and Personalized Medicine·C Hesse, J H Eisenach
Sep 12, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Yingxin PengRongbin Li
Jul 2, 2010·Biological Research for Nursing·Jacquelyn Y TaylorSharon L R Kardia
Mar 26, 2011·Genes & Nutrition·Rodrigo Gonçalves DiasAlexandre Costa Pereira
Mar 30, 2011·Hypertension·Andrew D JohnsonUNKNOWN Women's Genome Health Study
Aug 11, 2011·General and Comparative Endocrinology·Emma GiltrowMariann Rand-Weaver

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