mRNA-miRNA-Seq Reveals Neuro-Cardio Mechanisms of Crude Oil Toxicity in Red Drum ( Sciaenops ocellatus)

Environmental Science & Technology
Elvis Genbo XuDaniel Schlenk

Abstract

Polycyclic aromatic hydrocarbons (PAHs) present in crude oil can cause global gene dysregulation and developmental impairment in fish. However, the mechanisms that alter gene regulation are not well understood. In this study, larval red drum ( Sciaenops ocellatus) were exposed to water accommodated fractions of source oil (6.8, 13.7, and 35.9 μg/L total PAHs) and weathered slick oil (4.7, 8.1, and 18.0 μg/L total PAHs) from the Deepwater Horizon (DWH) oil spill. The global mRNA-microRNA functional networks associated with the toxicity of DWH oil were explored by next-generation sequencing and in-depth bioinformatics analyses. Both source and slick oil significantly altered the expression of miR-18a, miR-27b, and miR-203a across all exposure concentrations. Consistent with the observed concentration-dependent morphological changes, the target mRNAs of these microRNAs were predominantly involved in neuro-cardio system development processes and associated key signaling pathways such as axonal guidance signaling, cAMP-response-element-binding protein signaling in neurons, calcium signaling, and nuclear-factor-of-activated T cells signaling in cardiac hypertrophy. The results indicated that the developmental toxicity of crude oil ma...Continue Reading

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Citations

Apr 25, 2020·The Science of the Total Environment·A Bonisoli-AlquatiS S Taylor
Feb 2, 2021·Environmental Toxicology and Chemistry·Victoria McGruerDaniel Schlenk
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May 26, 2021·Environmental Science & Technology·Alexis J KhursigaraAndrew J Esbaugh
Sep 21, 2021·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Ryan TakeshitaAilsa J Hall

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