mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection.

Leonidas StamatatosAndrew T McGuire


Emerging SARS-CoV-2 variants have raised concerns about resistance to neutralizing antibodies elicited by previous infection or vaccination. We examined whether sera from recovered and naïve donors collected prior to, and following immunizations with existing mRNA vaccines, could neutralize the Wuhan-Hu-1 and B.1.351 variants. Pre-vaccination sera from recovered donors neutralized Wuhan-Hu-1 and sporadically neutralized B.1.351, but a single immunization boosted neutralizing titers against all variants and SARS-CoV-1 by up to 1000-fold. Neutralization was due to antibodies targeting the receptor binding domain and was not boosted by a second immunization. Immunization of naïve donors also elicited cross-neutralizing responses, but at lower titers. Our study highlights the importance of vaccinating both uninfected and previously infected persons to elicit cross-variant neutralizing antibodies.


Mar 29, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·One DintweStephen C De Rosa
May 13, 2019·Journal of Biomedical Informatics·Paul A HarrisUNKNOWN REDCap Consortium
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Feb 23, 2020·The Lancet Infectious Diseases·Ensheng DongLauren Gardner
Mar 11, 2020·Cell·Alexandra C WallsDavid Veesler
May 22, 2020·Science·Abishek ChandrashekarDan H Barouch
Jun 20, 2020·Nature·Davide F RobbianiMichel C Nussenzweig
Jul 7, 2020·JAMA : the Journal of the American Medical Association·Kevin P O'CallaghanPaul A Offit
Jul 15, 2020·Science·Meng YuanIan A Wilson
Jul 15, 2020·The New England Journal of Medicine·Lisa A JacksonUNKNOWN mRNA-1273 Study Group
Jul 25, 2020·Science·Ching-Lin HsiehJason S McLellan
Aug 7, 2020·Nature·Kizzmekia S CorbettBarney S Graham
Aug 25, 2020·Cell Reports Medicine·Mehul S SutharJens Wrammert
Sep 12, 2020·JAMA : the Journal of the American Medical Association·David S Stephens, M Juliana McElrath
Oct 1, 2020·BioRxiv : the Preprint Server for Biology·Ge SongRaiees Andrabi
Oct 15, 2020·The New England Journal of Medicine·Edward E WalshWilliam C Gruber

❮ Previous
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May 12, 2021·Nature Medicine·Emanuele Andreano, Rino Rappuoli
May 20, 2021·Cell Research·Jyothi N PurushothamVincent J Munster
Jun 3, 2021·Journal of Dental Research·A M ShieldsI L C Chapple
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Jul 20, 2021·Kidney Medicine·Matthew AbramsonFadi Salem
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