MRSA clones identified in outpatient dermatology clinics

Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Shino HosoyaKeiichi Hiramatsu

Abstract

To know the characteristics of methicillin-resistant Staphylococcus aureus (MRSA) strains disseminating through the Japanese community, we have determined types of Staphylococcal cassette chromosome mec (SCCmec) elements, Multi-Locus Sequence Typing (MLST), and carriages of four exotoxin genes (toxic-shock syndrome toxin, Panton-Valentine Leukocidine, and exfoliative toxins a and b) using 54 MRSA strains isolated from outpatients attending dermatology clinics at the four university hospitals of Juntendo University. Ten clonal complexes and 12 SCCmec types have been identified. As a result, more than 15 MRSA clones that were defined by the combination of genotype and SCCmec type, were identified. Among them, Clonal Complex (CC) 5-type IIa SCCmec strains were the most major (16 strains). In contrast to the fact that CC5- type IIa SCCmec strains known as a hospital-associated MRSA clone in Japan carried toxic-shock syndrome toxin gene (tst), only 2 of 16 strains have been shown to carry tst. Thirty-eight (70.4%) of isolates belonged to the clones distinct from the CC5-type IIa SCCmec strains. Among them, CC8 strains were major (12 strains), which contained 9 tst-positive CC8-type IVl SCCmec clones and a CC8-type IVa SCCmec strain ...Continue Reading

References

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Citations

May 21, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Meiji Soe AungNobumichi Kobayashi
Mar 28, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Atsushi TsujiwakiToshiaki Shimizu
Aug 9, 2019·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Yasunori Suzuki

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