PMID: 9533950May 12, 1998Paper

Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis

Mechanisms of Development
Sally L DunwoodieR Beddington

Abstract

Msg1 and Mrg1 are founding members of a gene family which exhibit distinct patterns of gene expression during mouse embryogenesis. Sequence analysis reveals that these genes are unlike any other gene identified to date, but they share two near-identical sequence domains. The Msg1 and Mrg1 expression profiles during early development are distinct from each other. Msg1 is predominantly expressed in nascent mesoderm, the heart tube, limb bud and sclerotome. Intriguingly, Msg1 expression is restricted, within these developing mesodermal sites, to posterior domains. Mrg1 is expressed prior to gastrulation in the anterior visceral endoderm. Expression is maintained in the endoderm once gastrulation has begun and commences in the rostralmost embryonic mesoderm which underlies the anterior visceral endoderm. Mrg1 expression persists in this rostral mesoderm as it is translocated caudalwards during the invagination of the foregut and the formation of the heart. Later Mrg1 expression predominates in the septum transversum caudal to the heart. This expression pattern suggests that the septum transversum originates from the rostralmost embryonic mesoderm which first expressed Mrg1 at the late primitive streak stage.

References

Jan 1, 1989·The Journal of Experimental Zoology·N WanekS V Bryant
Dec 1, 1988·Journal of Molecular Evolution·W R Taylor
Jan 1, 1988·Anatomy and Embryology·H J Kuhn, G Liebherr
Jan 1, 1987·Anatomy and Embryology·M KomiyamaY Shimada
Feb 1, 1969·Developmental Biology·H Stalsberg, R L DeHaan
Feb 1, 1971·Developmental Biology·R L Searls, M Y Janners
Nov 1, 1984·The Journal of Experimental Zoology·J Milaire, J Mulnard
Dec 1, 1983·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·I EmuraY Ohnishi
Sep 1, 1981·The Anatomical Record·S Virágh, C E Challice
Dec 14, 1995·Nature·A VogelJ C Izpisúa Belmonte
Nov 1, 1995·Genes & Development·I MatsuoS Aizawa
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·P MountfordA Smith
May 1, 1993·Trends in Genetics : TIG·B Rosen, R S Beddington
Jul 25, 1996·Nature·C A LoomisA L Joyner
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·T ShiodaK J Isselbacher

❮ Previous
Next ❯

Citations

Jun 22, 1999·Developmental Biology·B G BruneauC E Seidman
Jul 24, 1998·Trends in Genetics : TIG·R S Beddington, E J Robertson
Oct 8, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·P K S NgR Y C Kong
Oct 12, 2004·Nature Genetics·Simon D BamforthShoumo Bhattacharya
Jan 30, 2010·Cardiovascular Research·Mathilda T M MommersteegVincent M Christoffels
Apr 17, 2012·European Heart Journal·Simon T MacDonaldShoumo Bhattacharya
Jan 13, 2011·Human Molecular Genetics·Kylie Lopes FloroSally L Dunwoodie
Jan 14, 1999·Genes & Development·S BhattacharyaD M Livingston
Jan 7, 2003·Genes & Development·Ariel A AvilionRobin Lovell-Badge
Mar 10, 2001·Molecular and Cellular Biology·B G BruneauJ G Seidman
Dec 16, 2003·Molecular and Cellular Biology·Tristan A RodriguezSally L Dunwoodie
Aug 13, 2013·PLoS Genetics·Valérie MénielAlan R Clarke
Mar 14, 2012·PloS One·Yohei SaitoNaoki Takahashi
Oct 20, 2012·PloS One·Chiann-mun ChenShoumo Bhattacharya
Jul 15, 2009·The International Journal of Developmental Biology·Vasker BhattacherjeeRobert M Greene
Mar 20, 2009·Journal of the American Society of Nephrology : JASN·Duncan B SparrowMark P de Caestecker
Mar 30, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Michel GuillomotJean-Paul Renard
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Alistair J WattStephen A Duncan
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·T ShiodaK J Isselbacher
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Zhan YinYu-Chung Yang
Oct 31, 1998·Current Opinion in Genetics & Development·K Zaret
Apr 28, 2007·Seminars in Pediatric Surgery·Robin D Clugston, John J Greer
Mar 6, 2007·Journal of Pediatric Surgery·Harold N LovvornMark de Caestecker
Feb 5, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tadayoshi HayataKen W Y Cho
Jul 7, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Scott BoyleMark de Caestecker
Apr 17, 2013·The FEBS Journal·Allyson J Merrell, Gabrielle Kardon
Dec 19, 2006·Matrix Biology : Journal of the International Society for Matrix Biology·Renata MeszarosPeter Ekblom
Oct 27, 2011·Developmental Biology·Agnieszka PacaTilo Kunath
Nov 5, 2011·Developmental Biology·Jérôme ArtusAnna-Katerina Hadjantonakis
May 8, 2014·Developmental Biology·Julie L M MoreauSally L Dunwoodie
Apr 29, 2015·Developmental Biology·Tomasz M KulinskiQuanah J Hudson
Jul 25, 2000·Mechanisms of Development·J E AndrewsA H Sinclair

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.