MSGP: the first database of the protein components of the mammalian stress granules

Database : the Journal of Biological Databases and Curation
Catarina NunesClévio Nóbrega

Abstract

In response to different stress stimuli, cells transiently form stress granules (SGs) in order to protect themselves and re-establish homeostasis. Besides these important cellular functions, SGs are now being implicated in different human diseases, such as neurodegenerative disorders and cancer. SGs are ribonucleoprotein granules, constituted by a variety of different types of proteins, RNAs, factors involved in translation and signaling molecules, being capable of regulating mRNA translation to facilitate stress response. However, until now a complete list of the SG components has not been available. Therefore, we aimer at identifying and linting in an open access database all the proteins described so far as components of SGs. The identification was made through an exhaustive search of studies listed in PubMed and double checked. Moreover, for each identified protein several details were also gathered from public databases, such as the molecular function, the cell types in which they were detected, the type of stress stimuli used to induce SG formation and the reference of the study describing the recruitment of the component to SGs. Expression levels in the context of different neurodegenerative diseases were also obtained a...Continue Reading

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Citations

Nov 30, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Pankaj ThapaWojciech Pokrzywa
Oct 5, 2019·Nucleic Acids Research·Kaiqiang YouTingting Li
Jul 18, 2020·Acta Neuropathologica Communications·John L GoodierJose Luis García-Pérez
Nov 5, 2019·Frontiers in Cellular and Infection Microbiology·Aracelly Gaete-ArgelFernando Valiente-Echeverría
Nov 8, 2020·Cells·Christof HiebelChristian Behl
Feb 18, 2021·Journal of the American Chemical Society·Morgan DasovichAnthony K L Leung
Feb 23, 2021·Frontiers in Immunology·De Chen ChiangSiew Kit Ng
Mar 17, 2021·The FEBS Journal·Daniel Mateju, Jeffrey A Chao
May 13, 2021·Scientific Reports·Sonia T NicolaouJim Warwicker
Jun 10, 2021·Cell Death & Disease·Adriana MarceloClévio Nóbrega
May 5, 2021·The Journal of Clinical Investigation·Isabella I SanchezLeslie M Thompson
Aug 27, 2021·Frontiers in Plant Science·Israel Maruri-LópezMonika Chodasiewicz
Jan 25, 2022·FEBS Letters·András László SzabóZoltán Gáspári

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Methods Mentioned

BETA
biopsy

Software Mentioned

Elementor Page Builder
Geo2R
js
Wordpress
Vue
MSGP
Excel
PANTHER

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