MS(n) characterization of protonated cyclic peptides and metal complexes

Journal of the American Society for Mass Spectrometry
Sheldon M Williams, J S Brodbelt

Abstract

MS(n) experiments involving low energy collisionally activated dissociation (CAD) in a quadrupole ion trap were used to characterize the fragmentation of alkali, alkaline earth and transition metal complexes of five cyclic peptides, and the results were compared with those obtained for protonated cyclic peptides. Complexes with metal ions produced enhanced abundances of the most diagnostic fragments for elucidating the primary structures. For cyclosporin A, nickel and lithium complexes gave additional sequence information compared with the protonated peptide. For depsipeptides, sodium and lead complexes were superior to the protonated peptide or other metal complexes for sequencing residues, and CAD of the lead complexes led to preferential cleavage of two residues at a time. For cyclic lipopeptides, complexes with silver, nickel and strontium ions provided enhanced abundances of key fragment ions.

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Citations

Apr 16, 2011·Analytical and Bioanalytical Chemistry·Lada IvanovaSilvio Uhlig
May 3, 2012·Journal of the American Society for Mass Spectrometry·Cheng GuoYuanjiang Pan
Aug 3, 2013·Journal of the American Society for Mass Spectrometry·Laura BanuDiethard K Bohme
Jul 16, 2005·Journal of the American Society for Mass Spectrometry·Andrew R S Ross, Sarah L Luettgen
Jun 23, 2007·Journal of the American Society for Mass Spectrometry·Carolyn L MazzitelliJennifer S Brodbelt
Jul 25, 2013·Journal of Chemical Ecology·Wilna J MoreePieter C Dorrestein
Feb 13, 2016·Journal of the American Society for Mass Spectrometry·Christopher M CrittendenJennifer S Brodbelt
May 12, 2015·Applied Microbiology and Biotechnology·Wen-Xuan WangMichael Spiteller
Mar 3, 2009·Toxicon : Official Journal of the International Society on Toxinology·Silvio UhligRalf Kristensen
Jun 17, 2015·Organic & Biomolecular Chemistry·Serge ZaretskyAndrei K Yudin
May 12, 2007·Mass Spectrometry Reviews·Otilia MóJeanine Tortajada
Jan 22, 2008·Journal of Mass Spectrometry : JMS·Dan PuCarolyn J Cassady
May 10, 2005·Journal of Mass Spectrometry : JMS
Apr 9, 2008·Journal of the American Chemical Society·Thomas WyttenbachMichael T Bowers

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