MSX1 gene polymorphisms in non-syndromic cleft lip and/or palate

Oral Diseases
M L CardosoA A Rezende

Abstract

The aim of this study was to investigate the contribution of 6 polymorphic variants of the MSX1 gene in non-syndromic cleft lip and/or palate (NSCL/P). Three hundred and fifty-eight individuals (158 NSCL/P cases and 200 controls) were genotyped by TaqMan allelic discrimination using predesigned SNP assays. Statistical analyses were conducted using the software spss 15.0 and the r statistical suite. Haplotype block structure and haplotype frequencies were determined using the Haploview. A P-value of 0.05 and confidence interval of 95% were used for all of statistical tests. The patients with non-syndromic cleft lip and/or palate were characterized by similar distribution of MSX1 genotypes and allele in comparison to subjects without oral clefts (P > 0.05). Two haplotype blocks were constructed with polymorphisms of MSX1 gene and haplotypes formed showed a similar frequency in patients with and without oral clefts. The present study provides no evidence that MSX1 polymorphisms (rs3775261, rs1042484, rs12532, rs6446693, rs4464513 and rs1907998) play a major role in NSCL/P.

References

Feb 1, 1994·Journal of Medical Genetics·David R FitzpatrickJ G Boorman
Nov 28, 2000·The British Journal of Oral & Maxillofacial Surgery·Nagato NatsumeH Sunakawa
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·C Blin-WakkachA Berdal
Jan 5, 2002·Genetic Epidemiology·Terri H BeatyIain McIntosh
May 25, 2002·Science·Stacey B GabrielDavid Altshuler
May 29, 2002·Clinical Genetics·J C Murray
Mar 26, 2003·Journal of Dental Research·A R VieiraJ C Murray
Jun 17, 2003·Journal of Medical Genetics·Peter A JezewskiJ C Murray
Aug 14, 2003·Genetic Epidemiology·M Daniele FallinTerri H Beaty
Jan 20, 2004·Cell Research·Sylvia AlappatYi Ping Chen
Feb 3, 2004·American Journal of Medical Genetics. Part a·R E SchultzJeffrey C Murray
Feb 26, 2004·American Journal of Medical Genetics. Part a·Lina M MorenoAndrew C Lidral
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Sep 10, 2004·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Yasushi SuzukiJeffrey C Murray
Sep 24, 2004·Journal of Dental Research·José SuazoRafael Blanco
Feb 4, 2005·Nature·Joel D Richter, Nahum Sonenberg
Nov 12, 2005·Current Opinion in Pediatrics·Andrew C Lidral, Lina M Moreno
Nov 25, 2005·Current Molecular Medicine·David P C Rice
Dec 6, 2005·PLoS Genetics·Alexandre R VieiraJeffrey C Murray
Jan 8, 2008·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Liliana OteroLuis Bérmudez
Jan 26, 2008·Journal of Dental Research·A R Vieira
Apr 3, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Min ShiJeffrey C Murray
Apr 30, 2008·American Journal of Medical Genetics. Part a·Alexandre R VieiraM L Marazita
Sep 16, 2008·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Rachael Fels ElliottMassey Beveridge
Apr 7, 2009·The Tohoku Journal of Experimental Medicine·Elzbieta PawlowskaJanusz Blasiak
Jun 3, 2009·Brazilian Oral Research·Katamara RodriguesMaria Angela Fernandes Ferreira
Nov 4, 2009·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Wenli YuKathy K H Svoboda
Mar 25, 2010·Oral Diseases·G L Wehby, Jeffrey C Murray
Jun 19, 2010·The New England Journal of Medicine·Janneke JentinkEUROCAT Antiepileptic Study Working Group
Jun 22, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Augusto Rojas-MartinezElisabeth Mangold
Jun 25, 2010·European Journal of Oral Sciences·Triin JagomägiAndres Metspalu
Jul 17, 2010·American Journal of Medical Genetics. Part a·José SuazoRafael Blanco
Feb 19, 2011·Nature Reviews. Genetics·Michael J DixonJeffrey C Murray
Jun 22, 2011·DNA and Cell Biology·Yong-qing HuangBing Shi
Aug 26, 2011·Journal of Human Genetics·Iman SalahshourifarBin Alwi Zilfalil
Oct 7, 2011·International Journal of Paediatric Dentistry·Varun P Singh, Dinesh Ramu

Citations

Apr 4, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Fang LuanHaixia Zhang
Feb 4, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yue HanYongchu Pan
Sep 25, 2015·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Renato Assis MachadoRicardo D Coletta
Oct 13, 2016·International Journal of Pediatric Otorhinolaryngology·Aurora Ibarra-ArceAngélica Olivo-Díaz
Aug 2, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L T SouzaT M Félix
Mar 8, 2014·Journal of Dental Research·L MaL Wang
Apr 18, 2018·European Journal of Oral Sciences·Min GuXu Yang
Mar 8, 2018·Journal of Clinical Laboratory Analysis·Heglayne Pereira Vital da SilvaAdriana Augusto de Rezende
Jun 30, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jihong Du, Jianhua Deng

Related Concepts

MSX1 protein, human
Cleft Lip
Cleft Palate, Isolated
Nested Case-Control Studies
Single Nucleotide Polymorphism
MSX1 Transcription Factor
Alleles
Cleft Palate
Computer Software
Statistical Test

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