Mt-rps3 is an ancient gene which provides insight into the evolution of fungal mitochondrial genomes

Molecular Phylogenetics and Evolution
Artemis G KorovesiVassili N Kouvelis

Abstract

The nuclear ribosomal protein S3 (Rps3) is implicated in the assembly of the ribosomal small subunit. Fungi and plants present a gene copy in their mitochondrial (mt) genomes. An analysis of 303 complete fungal mt genomes showed that, when rps3 is found, it is either a free-standing gene or an anchored gene within the omega intron of the rnl gene. Early divergent fungi, Basidiomycota and all yeasts but the CTG group belong to the first case, and Pezizomycotina to the second. Its position, size and genetic code employed are conserved within species of the same Order. Size variability is attributed to different number of repeats. These repeats consist of AT-rich sequences. MtRps3 proteins lack the KH domain, necessary for binding to rRNA, in their N-terminal region. Their C-terminal region is conserved in all Domains of life. Phylogenetic analysis showed that nuclear and mtRps3 proteins are descendants of archaeal and a-proteobacterial homologues, respectively. Thus, fungal mt-rps3 gene is an ancient gene which evolved within the endosymbiotic model and presents different evolutionary routes: (a) coming from a-proteobacteria, it was relocated to another region of the mt genome, (b) via its insertion to the omega intron, it was tr...Continue Reading

Citations

Mar 9, 2019·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Alvan WaiGeorg Hausner
Apr 10, 2020·Genome Biology and Evolution·Benjamin SchwessingerAnnemarie Fejer Justesen
Apr 3, 2020·G3 : Genes - Genomes - Genetics·Leandro Ferreira MorenoSybren de Hoog
Jun 26, 2020·Genome Biology and Evolution·Amalia H Megarioti, Vassili N Kouvelis
Jul 19, 2018·Nature Reviews. Genetics·Daniel B SloanJustin C Havird
Apr 20, 2021·G3 : Genes - Genomes - Genetics·Marcus de Melo TeixeiraBridget Barker
Nov 16, 2021·Frontiers in Microbiology·Shahin S AliBryan A Bailey

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