MT1-MMP as a PET Imaging Biomarker for Pancreas Cancer Management

Contrast Media & Molecular Imaging
M Á MorcilloJ L Martinez-Torrecuadrada

Abstract

Pancreatic ductal adenocarcinoma (PDAC) continues to be one of the deadliest cancers for which optimal diagnostic tools are still greatly needed. Identification of PDAC-specific molecular markers would be extremely useful to improve disease diagnosis and follow-up. MT1-MMP has long been involved in pancreatic cancer, especially in tumour invasion and metastasis. In this study, we aim to ascertain the suitability of MT1-MMP as a biomarker for positron emission tomography (PET) imaging. Two probes were assessed and compared for this purpose, an MT1-MMP-specific binding peptide (MT1-AF7p) and a specific antibody (LEM2/15), labelled, respectively, with 68Ga and with 89Zr. PET imaging with both probes was conducted in patient-derived xenograft (PDX), subcutaneous and orthotopic, PDAC mouse models, and in a cancer cell line (CAPAN-2)-derived xenograft (CDX) model. Both radiolabelled tracers were successful in identifying, by means of PET imaging techniques, tumour tissues expressing MT1-MMP although they did so at different uptake levels. The 89Zr-DFO-LEM2/15 probe showed greater specific activity compared to the 68Ga-labelled peptide. The mean value of tumour uptake for the 89Zr-DFO-LEM2/15 probe (5.67 ± 1.11%ID/g, n=28) was 25-30 t...Continue Reading

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Citations

Feb 4, 2021·Bioengineering & Translational Medicine·Natacha JugniotRamasamy Paulmurugan
Apr 4, 2021·Journal of Clinical Medicine·Ruth González-GómezAlberto J Schuhmacher
Jul 3, 2021·International Journal of Molecular Sciences·Christopher MontemagnoGilles Pagès
Mar 24, 2020·Chemical Reviews·Weijun WeiWeibo Cai

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Methods Mentioned

BETA
imaging techniques
xenograft
size-exclusion chromatography
Xenografts

Software Mentioned

SNAP
GraphPad
CIEMAT
Pannoramic Viewer
ITK

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